4G1T.B | IFIT2

General Structure Information

PDB ID	4g1t
HGNC Gene Label(s)	IFIT2
Structure Name	crystal structure of interferon-stimulated gene 54
Resolution	2.8Å
Reference	AUTH Z.YANG,H.LIANG,Q.ZHOU,Y.LI,H.CHEN,W.YE,D.CHEN,J.FLEMING,AUTH 2 H.SHU,Y.LIUTITL CRYSTAL STRUCTURE OF ISG54 REVEALS A NOVEL RNA BINDINGTITL 2 STRUCTURE AND POTENTIAL FUNCTIONAL MECHANISMS.REF CELL RES. 2012REFN ISSN 1001-0602PMID 22825553DOI 10.1038/CR.2012.111

Variant Set Distributions

ExAC Variants

Number Of Residues	429
Number Of SNVs	108
Number Of Permutations	32318
Optimal Distance Threshold	12.0
K Statistic	0.052
p-value	0.588

COSMIC

Number Of Residues	429
Number Of SNVs	6
Number Of Permutations	2236
Optimal Distance Threshold	19.0
K Statistic	0.067
p-value	0.632

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	108
Number Of COSMIC SNVs	6
Optimal Distance Threshold	37.0
K Statistic	-0.201
p-value	0.592

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:91065743		E>D	B:10	(4.18, 18.13, -17.18)
10:91065746		S>R	B:11	(8.44, 16.14, -16.64)
10:91065747		S>R	B:12	(7.30, 13.60, -14.14)
10:91065750		L>V	B:13	(3.29, 13.67, -14.60)
10:91065754		R>Q	B:14	(4.28, 13.15, -20.31)
10:91065775	rs369117025	T>S	B:21	(0.53, 9.36, -21.49)
10:91065788		M>I	B:25	(-7.44, 13.25, -29.02)
10:91065805		L>W	B:31	(-14.10, 16.95, -27.77)
10:91065819		D>N	B:36	(-20.58, 11.56, -29.33)
10:91065829		F>Y	B:39	(-22.51, 8.51, -24.85)
10:91065834	rs543713702 COSM3441380	R>W	B:41	(-18.10, 3.00, -29.40)
10:91065835	rs376108562	R>Q	B:41	(-18.10, 3.00, -29.40)
10:91065841		E>G	B:43	(-25.60, 3.33, -24.88)
10:91065843		F>L	B:44	(-22.77, -0.63, -26.86)
10:91065870		M>V	B:53	(-15.67, 2.70, -19.26)
10:91065885		A>T	B:58	(-12.38, 10.62, -16.60)
10:91065891		L>V	B:60	(-14.02, 12.70, -21.81)
10:91065915	rs532385968	E>K	B:68	(-14.40, 17.99, -8.95)
10:91065922		A>G	B:70	(-13.25, 13.22, -13.19)
10:91065936		R>C	B:75	(-15.13, 7.55, -5.91)
10:91065940		K>I	B:76	(-16.98, 5.65, -9.60)
10:91065945	rs540819967	E>K	B:78	(-10.09, 3.09, -6.68)
10:91065963		E>K	B:84	(-13.18, -6.50, -10.61)
10:91065965		E>D	B:84	(-13.18, -6.50, -10.61)
10:91065966		H>Y	B:85	(-8.87, -7.56, -9.83)
10:91065968		H>Q	B:85	(-8.87, -7.56, -9.83)
10:91065974		D>E	B:87	(-4.79, -9.88, -4.76)
10:91065990		S>C	B:93	(-4.58, 0.73, -9.39)
10:91065996	rs375168880	V>I	B:95	(-3.94, 3.64, -14.88)
10:91066006		G>E	B:98	(-2.33, 8.79, -12.99)
10:91066039		R>Q	B:109	(-6.05, 19.26, -5.99)
10:91066050	COSM4016499 COSM1627664	V>I	B:113	(-0.24, 15.30, -7.32)
10:91066062		V>I	B:117	(3.32, 10.05, -7.41)
10:91066065	rs370489231	D>N	B:118	(4.18, 9.15, -3.24)
10:91066075	rs2070845	K>R	B:121	(7.21, 6.71, -6.71)
10:91066077		H>N	B:122	(5.63, 1.41, -2.66)
10:91066078		H>R	B:122	(5.63, 1.41, -2.66)
10:91066086	rs536483989	E>K	B:125	(10.05, 0.90, -5.62)
10:91066107	COSM3441381	R>G	B:132	(12.04, -5.82, -19.11)
10:91066110		I>V	B:133	(14.42, -0.69, -18.52)
10:91066113		E>K	B:134	(9.70, 0.72, -19.96)
10:91066114		E>G	B:134	(9.70, 0.72, -19.96)
10:91066126		L>R	B:138	(15.26, 0.52, -25.13)
10:91066140		G>W	B:143	(12.48, 0.14, -34.47)
10:91066146	rs140575157	T>S	B:145	(15.56, -3.47, -35.81)
10:91066149	rs368254015	R>W	B:146	(10.65, -4.58, -35.01)
10:91066181	rs187537532	R>S	B:156	(5.63, -4.39, -33.14)
10:91066183	COSM921250	A>V	B:157	(7.96, 0.10, -35.89)
10:91066198		E>G	B:162	(3.99, 5.96, -31.82)
10:91066243	rs372337866	G>A	B:177	(11.04, 6.98, -37.63)
10:91066248		A>P	B:179	(8.17, 8.99, -40.67)
10:91066252	rs539260313	I>T	B:180	(10.44, 6.16, -42.34)
10:91066285		S>C	B:191	(-1.13, -8.35, -43.73)
10:91066293	rs144300435	A>T	B:194	(-8.56, -12.54, -38.11)
10:91066297	rs200869366	I>S	B:195	(-9.83, -16.25, -39.42)
10:91066301		D>E	B:196	(-6.40, -17.72, -36.93)
10:91066321		R>Q	B:203	(-11.99, -23.30, -27.87)
10:91066324		L>P	B:204	(-9.57, -19.37, -24.97)
10:91066327		N>S	B:205	(-13.39, -16.74, -24.52)
10:91066329		P>T	B:206	(-16.71, -20.08, -23.98)
10:91066339		Q>L	B:209	(-21.56, -15.47, -27.39)
10:91066347		K>Q	B:212	(-19.39, -16.99, -31.44)
10:91066348	rs375598427	K>R	B:212	(-19.39, -16.99, -31.44)
10:91066378		M>R	B:222	(-13.84, -14.76, -47.07)
10:91066380	rs370009481	R>C	B:223	(-19.60, -17.65, -47.89)
10:91066381		R>H	B:223	(-19.60, -17.65, -47.89)
10:91066402		G>D	B:230	(-23.19, -22.51, -43.04)
10:91066407		G>R	B:232	(-22.31, -18.91, -39.97)
10:91066411		E>G	B:233	(-26.43, -19.53, -40.79)
10:91066412		E>D	B:233	(-26.43, -19.53, -40.79)
10:91066420		V>A	B:236	(-25.14, -16.10, -35.49)
10:91066446	rs41284134	G>R	B:245	(-29.17, -8.78, -24.55)
10:91066464	rs537050168 COSM1349699	R>C	B:251	(-23.95, -3.95, -33.29)
10:91066474		A>V	B:254	(-27.79, -7.43, -38.06)
10:91066505		D>E	B:264	(-36.77, -8.29, -42.47)
10:91066506	rs377588926	K>E	B:265	(-33.81, -11.89, -39.66)
10:91066510	rs370750247 COSM921252	A>V	B:266	(-31.93, -7.11, -38.93)
10:91066513	rs140944939	I>T	B:267	(-35.10, -4.53, -38.83)
10:91066515		E>K	B:268	(-37.00, -7.58, -35.61)
10:91066530		A>T	B:273	(-31.37, -3.07, -28.98)
10:91066531		A>D	B:273	(-31.37, -3.07, -28.98)
10:91066542		I>L	B:277	(-30.11, 1.53, -26.13)
10:91066546		P>R	B:278	(-33.50, 4.33, -26.26)
10:91066557		Y>N	B:282	(-23.21, 4.55, -33.84)
10:91066569		Q>E	B:286	(-27.36, -0.30, -38.46)
10:91066588		R>K	B:292	(-31.56, 2.78, -48.45)
10:91066606	rs61729485	V>A	B:298	(-39.73, -3.75, -52.69)
10:91066614		L>I	B:301	(-39.88, -7.50, -57.01)
10:91066621		E>G	B:303	(-44.28, -8.71, -59.82)
10:91066633	rs3898075	Y>C	B:307	(-45.48, -4.25, -53.57)
10:91066650		L>M	B:313	(-44.66, 5.36, -48.68)
10:91066660		I>T	B:316	(-39.66, 5.58, -47.30)
10:91066668	COSM466059	A>T	B:319	(-35.91, 5.20, -42.66)
10:91066684		K>R	B:324	(-34.57, 12.95, -38.65)
10:91066692	COSM3791017	D>N	B:327	(-28.86, 14.38, -38.89)
10:91066702	rs182750115	N>S	B:330	(-24.14, 13.48, -34.88)
10:91066716	rs368019671	R>C	B:335	(-20.76, 12.39, -43.09)
10:91066717		R>H	B:335	(-20.76, 12.39, -43.09)
10:91066764		E>K	B:351	(-40.60, 20.72, -49.04)
10:91066771		A>G	B:353	(-35.54, 16.71, -50.83)
10:91066775	rs371414597	E>D	B:354	(-34.96, 20.68, -52.15)
10:91066819		A>V	B:369	(-19.27, 12.91, -54.01)
10:91066830		L>F	B:373	(-24.71, 15.43, -55.18)
10:91066839	rs367905315	R>W	B:376	(-28.35, 10.45, -57.50)
10:91066840	rs199839737	R>P	B:376	(-28.35, 10.45, -57.50)
10:91066843	rs371767716	Y>C	B:377	(-30.20, 18.33, -57.16)
10:91066856		Q>H	B:381	(-34.07, 19.20, -60.71)
10:91066861		Y>F	B:383	(-36.03, 12.62, -64.60)
10:91066872		C>G	B:387	(-36.19, 21.93, -63.91)
10:91066885		A>V	B:391	(-29.72, 19.75, -64.52)
10:91066922		Q>H	B:403	(-12.71, 12.59, -60.80)
10:91066931		R>S	B:406	(-19.33, 6.32, -63.96)
10:91066978		R>Q	B:422	(-31.26, 22.58, -76.31)
10:91066986		K>E	B:425	(-36.26, 22.52, -81.17)
10:91067014		H>P	B:434	(-20.81, 23.81, -77.04)
10:91067047	rs138979563	K>R	B:445	(-8.16, 12.69, -74.70)
10:91067049	rs148978582	M>V	B:446	(-9.80, 9.63, -73.62)
10:91067050		M>K	B:446	(-9.80, 9.63, -73.62)
10:91067059	rs186703110	A>E	B:449	(-5.82, 6.14, -72.80)
10:91067062	rs368741645	D>G	B:450	(-7.40, 3.18, -73.97)

4G1T.B | IFIT2.

4G1T.B | IFIT2

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants