General Structure Information
| PDB ID | 3w14 |
| HGNC Gene Label(s) | INSR |
| Structure Name | insulin receptor ectodomain construct comprising domains l1,cr,l2, fniii-1 and alphact peptide in complex with bovine insulin and fab 83-14 |
| Resolution | 4.4Å |
| Reference | AUTH J.G.MENTING,J.WHITTAKER,M.B.MARGETTS,L.J.WHITTAKER,AUTH 2 G.K.-W.KONG,B.J.SMITH,C.J.WATSON,L.ZAKOVA,E.KLETVIKOVA,AUTH 3 J.JIRACEK,S.J.CHAN,D.F.STEINER,G.G.DODSON,A.M.BRZOZOWSKI,AUTH 4 M.A.WEISS,C.W.WARD,M.C.LAWRENCETITL HOW INSULIN ENGAGES ITS PRIMARY BINDING SITE ON THE INSULINTITL 2 RECEPTORREF NATURE V. 493 241 2013REFN ISSN 0028-0836PMID 23302862DOI 10.1038/NATURE11781 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 580 |
| Number Of SNVs | 103 |
| Number Of Permutations | 40448 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.06 |
| p-value | 0.433 |
ClinVar
| Number Of Residues | 580 |
| Number Of SNVs | 13 |
| Number Of Permutations | 6721 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.064 |
| p-value | 0.163 |
COSMIC
| Number Of Residues | 580 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2875 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.2 |
| p-value | 0.442 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 103 |
| Number Of ClinVar SNVs | 12 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.057 |
| p-value | 0.153 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 103 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.125 |
| p-value | 0.598 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
