General Structure Information
| PDB ID | 4dy0 |
| HGNC Gene Label(s) | SERPINE2 |
| Structure Name | crystal structure of native protease nexin-1 with heparin |
| Resolution | 2.35Å |
| Reference | AUTH W.LI,J.A.HUNTINGTONTITL CRYSTAL STRUCTURES OF PROTEASE NEXIN-1 IN COMPLEX WITHTITL 2 HEPARIN AND THROMBIN SUGGEST A 2-STEP RECOGNITION MECHANISM.REF BLOOD V. 120 459 2012REFN ISSN 0006-4971PMID 22618708DOI 10.1182/BLOOD-2012-03-415869 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 370 |
| Number Of SNVs | 89 |
| Number Of Permutations | 54511 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.007 |
| p-value | 0.622 |
COSMIC
| Number Of Residues | 370 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1052 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.2 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 89 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.294 |
| p-value | 0.503 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
