General Structure Information
| PDB ID | 3lco |
| HGNC Gene Label(s) | CSF1R |
| Structure Name | inhibitor bound to a dfg-out structure of the kinase domain of csf-1r |
| Resolution | 3.4Å |
| Reference | AUTH M.J.MEYERS,M.PELC,S.KAMTEKAR,J.DAY,G.I.PODA,M.K.HALL,AUTH 2 M.L.MICHENER,B.A.REITZ,K.J.MATHIS,B.S.PIERCE,M.D.PARIKH,AUTH 3 D.A.MISCHKE,S.A.LONG,J.J.PARLOW,D.R.ANDERSON,A.THORARENSENTITL STRUCTURE-BASED DRUG DESIGN ENABLES CONVERSION OF A DFG-INTITL 2 BINDING CSF-1R KINASE INHIBITOR TO A DFG-OUT BINDING MODE.REF BIOORG.MED.CHEM.LETT. V. 20 1543 2010REFN ISSN 0960-894XPMID 20137931DOI 10.1016/J.BMCL.2010.01.078 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 293 |
| Number Of SNVs | 50 |
| Number Of Permutations | 6232 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.162 |
| p-value | 0.137 |
ClinVar
| Number Of Residues | 293 |
| Number Of SNVs | 31 |
| Number Of Permutations | 4025 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.486 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 50 |
| Number Of ClinVar SNVs | 31 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.236 |
| p-value | 0.0 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
