General Structure Information
| PDB ID | 3kqs |
| HGNC Gene Label(s) | PNMT |
| Structure Name | crystal structure of hpnmt in complex adohcy and 2-aminobenzimidazole |
| Resolution | 2.0Å |
| Reference | AUTH N.DRINKWATER,H.VU,K.M.LOVELL,K.R.CRISCIONE,B.M.COLLINS,AUTH 2 T.E.PRISINZANO,S.A.POULSEN,M.J.MCLEISH,G.L.GRUNEWALD,AUTH 3 J.L.MARTINTITL FRAGMENT-BASED SCREENING BY X-RAY CRYSTALLOGRAPHY, MS ANDTITL 2 ISOTHERMAL TITRATION CALORIMETRY TO IDENTIFY PNMTTITL 3 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE) INHIBITORS.REF BIOCHEM.J. V. 431 51 2010REFN ISSN 0264-6021PMID 20642456DOI 10.1042/BJ20100651 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 268 |
| Number Of SNVs | 79 |
| Number Of Permutations | 26501 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.064 |
| p-value | 0.936 |
COSMIC
| Number Of Residues | 268 |
| Number Of SNVs | 5 |
| Number Of Permutations | 198 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.1 |
| p-value | 0.368 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 79 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.204 |
| p-value | 0.244 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
