General Structure Information
| PDB ID | 1cjl |
| HGNC Gene Label(s) | CTSL |
| Structure Name | crystal structure of a cysteine protease proform |
| Resolution | 2.2Å |
| Reference | AUTH R.COULOMBE,P.GROCHULSKI,J.SIVARAMAN,R.MENARD,AUTH 2 J.S.MORT,M.CYGLERTITL STRUCTURE OF HUMAN PROCATHEPSIN L REVEALS THETITL 2 MOLECULAR BASIS OF INHIBITION BY THE PROSEGMENT.REF EMBO J. V. 15 5492 1996REFN ISSN 0261-4189PMID 8896443 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 215 |
| Number Of SNVs | 53 |
| Number Of Permutations | 31823 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.253 |
| p-value | 0.51 |
COSMIC
| Number Of Residues | 215 |
| Number Of SNVs | 5 |
| Number Of Permutations | 646 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.3 |
| p-value | 0.778 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | -0.29 |
| p-value | 0.418 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
