1ZCM.A | CAPN1

General Structure Information

PDB ID	1zcm
HGNC Gene Label(s)	CAPN1
Structure Name	human calpain protease core inhibited by zllych2f
Resolution	2.0Å
Reference	AUTH Q.LI,R.P.HANZLIK,R.F.WEAVER,E.SCHONBRUNNTITL MOLECULAR MODE OF ACTION OF A COVALENTLYTITL 2 INHIBITING PEPTIDOMIMETIC ON THE HUMAN CALPAINTITL 3 PROTEASE COREREF BIOCHEMISTRY V. 45 701 2006REFN ISSN 0006-2960PMID 16411745DOI 10.1021/BI052077B

Variant Set Distributions

ExAC Variants

Number Of Residues	321
Number Of SNVs	74
Number Of Permutations	38052
Optimal Distance Threshold	15.0
K Statistic	0.144
p-value	0.127

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:64950309		R>Q	A:46	(-55.13, -6.36, 46.20)
11:64950312		V>A	A:47	(-56.89, -10.18, 47.55)
11:64950335		L>V	A:55	(-49.97, -4.28, 54.90)
11:64950341		R>C	A:57	(-44.30, -7.66, 55.54)
11:64950342		R>H	A:57	(-44.30, -7.66, 55.54)
11:64950346		D>E	A:58	(-41.38, -8.27, 48.94)
11:64950356		P>S	A:62	(-36.58, -7.32, 51.68)
11:64950357		P>H	A:62	(-36.58, -7.32, 51.68)
11:64950365		P>T	A:65	(-29.80, -3.75, 54.65)
11:64950372		S>I	A:67	(-32.31, -3.97, 49.54)
11:64950380		Y>H	A:70	(-23.35, -3.46, 46.92)
11:64950393	rs201318945	G>D	A:74	(-23.98, -0.81, 53.04)
11:64950396		P>H	A:75	(-24.54, -2.86, 55.75)
11:64950407		K>E	A:79	(-23.58, 6.98, 51.92)
11:64950411		T>S	A:80	(-26.88, 4.00, 55.45)
11:64950430		K>N	A:86	(-41.12, 4.44, 57.04)
11:64950432		R>H	A:87	(-45.50, 0.76, 54.25)
11:64950438		T>M	A:89	(-49.34, 4.89, 54.78)
11:64950603		L>P	A:91	(-44.71, 9.19, 55.96)
11:64950611		N>Y	A:94	(-54.09, 11.04, 52.25)
11:64950618		Q>P	A:96	(-51.89, 10.27, 46.60)
11:64950633	rs534135243	G>A	A:101	(-50.03, 13.08, 37.05)
11:64950635		A>T	A:102	(-47.52, 10.95, 35.46)
11:64950638	rs17885718	T>A	A:103	(-45.34, 14.06, 35.11)
11:64950641		R>C	A:104	(-41.81, 16.22, 32.50)
11:64950642	rs201751778	R>H	A:104	(-41.81, 16.22, 32.50)
11:64950650	COSM3398040	I>F	A:107	(-38.64, 12.32, 38.01)
11:64950652		I>M	A:107	(-38.64, 12.32, 38.01)
11:64950963		A>V	A:119	(-34.21, 10.10, 32.35)
11:64950989		D>N	A:128	(-49.93, 8.36, 27.60)
11:64951005		R>Q	A:133	(-47.32, -1.85, 29.38)
11:64951014		P>L	A:136	(-49.93, 0.60, 36.72)
11:64951016		H>N	A:137	(-52.18, 4.86, 35.92)
11:64951020		G>A	A:138	(-55.22, 2.97, 39.97)
11:64951043		A>T	A:146	(-52.30, -3.69, 50.66)
11:64951046		G>S	A:147	(-48.98, -2.53, 50.24)
11:64951049		I>L	A:148	(-49.04, -4.32, 46.77)
11:64953389		L>R	A:153	(-40.39, -3.67, 33.59)
11:64953398		F>S	A:156	(-33.67, -9.89, 30.08)
11:64953406		W>G	A:159	(-43.36, -5.64, 28.60)
11:64953415		V>M	A:162	(-42.56, -6.00, 39.11)
11:64953434	rs375914303	L>P	A:168	(-40.02, 3.68, 50.34)
11:64953463	rs372952178	V>L	A:178	(-36.91, 9.14, 43.56)
11:64953473		A>V	A:181	(-42.09, 17.78, 43.41)
11:64953475	rs534196812	E>K	A:182	(-45.97, 17.19, 44.95)
11:64953497	rs202175767	A>D	A:189	(-40.57, 5.81, 44.15)
11:64953514		Y>D	A:195	(-35.05, -0.72, 37.11)
11:64953673		G>V	A:208	(-25.58, 3.90, 33.63)
11:64953679		T>I	A:210	(-30.31, 6.08, 29.41)
11:64953693		E>K	A:215	(-34.05, -0.63, 25.65)
11:64953708	rs567507506 COSM1171824	G>R	A:220	(-36.94, -1.12, 22.20)
11:64953717		E>K	A:223	(-30.85, 5.34, 17.45)
11:64953718		E>A	A:223	(-30.85, 5.34, 17.45)
11:64953732		R>C	A:228	(-18.01, 16.29, 18.65)
11:64953733	COSM295128	R>H	A:228	(-18.01, 16.29, 18.65)
11:64953745		S>I	A:232	(-27.96, 17.07, 8.30)
11:64953762		I>V	A:238	(-34.96, 15.06, 17.30)
11:64953772		A>V	A:241	(-39.12, 10.95, 17.59)
11:64953778		E>A	A:243	(-44.57, 12.80, 16.17)
11:64953780		R>W	A:244	(-41.85, 8.30, 16.28)
11:64953781		R>Q	A:244	(-41.85, 8.30, 16.28)
11:64953787	rs374219289	S>F	A:246	(-39.62, 8.07, 20.94)
11:64953805		I>T	A:252	(-21.92, 16.10, 28.58)
11:64954692		S>R	A:256	(-11.83, 14.43, 33.34)
11:64954695	rs11554993	V>I	A:257	(-12.02, 10.84, 35.35)
11:64954704		M>V	A:260	(-18.01, 12.03, 37.84)
11:64954706		M>I	A:260	(-18.01, 12.03, 37.84)
11:64954711	rs192099450	A>D	A:262	(-19.78, 18.49, 36.75)
11:64954761		A>T	A:279	(-38.89, 20.23, 19.82)
11:64955459	rs368843790	R>W	A:293	(-38.42, 20.55, 26.16)
11:64955466		R>Q	A:295	(-36.12, 17.05, 33.61)
11:64955493	rs377052700 COSM930346	T>M	A:304	(-27.47, 29.93, 31.96)
11:64955898		N>D	A:315	(-38.29, 39.16, 25.26)
11:64955910		P>S	A:319	(-46.56, 36.15, 22.16)
11:64955913	rs370989378	Y>H	A:320	(-49.13, 30.55, 21.33)
11:64955919	rs567949433	R>W	A:322	(-43.44, 34.53, 25.17)
11:64955920	rs537382083	R>Q	A:322	(-43.44, 34.53, 25.17)
11:64955938	rs550600375	K>R	A:328	(-40.19, 32.10, 34.23)
11:64955939		K>N	A:328	(-40.19, 32.10, 34.23)
11:64956066		F>L	A:338	(-29.79, 21.65, 17.23)
11:64956068		R>Q	A:339	(-24.98, 26.50, 16.77)
11:64956079		R>W	A:343	(-20.73, 24.92, 21.32)
11:64956080	COSM1289606	R>Q	A:343	(-20.73, 24.92, 21.32)
11:64956089	rs192790363	T>I	A:346	(-21.43, 14.56, 23.44)
11:64956091	rs200456847	R>C	A:347	(-23.74, 10.18, 23.84)
11:64956092	rs372172705	R>H	A:347	(-23.74, 10.18, 23.84)