4G1M.A | ITGAV

General Structure Information

PDB ID	4g1m
HGNC Gene Label(s)	ITGAV
Structure Name	re-refinement of alpha v beta 3 structure
Resolution	2.9Å
Reference	AUTH X.DONG,L.Z.MI,J.ZHU,W.WANG,P.HU,B.H.LUO,T.A.SPRINGERTITL ALPHA V BETA 3 INTEGRIN CRYSTAL STRUCTURES AND THEIRTITL 2 FUNCTIONAL IMPLICATIONSREF BIOCHEMISTRY V. 51 8814 2012REFN ISSN 0006-2960PMID 23106217DOI 10.1021/BI300734N

Variant Set Distributions

ExAC Variants

Number Of Residues	929
Number Of SNVs	250
Number Of Permutations	92817
Optimal Distance Threshold	7.0
K Statistic	0.009
p-value	0.701

COSMIC

Number Of Residues	929
Number Of SNVs	8
Number Of Permutations	5327
Optimal Distance Threshold	9.0
K Statistic	0.071
p-value	0.558

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	250
Number Of COSMIC SNVs	9
Optimal Distance Threshold	64.0
K Statistic	0.301
p-value	0.276

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:187455167		D>E	A:4	(-11.38, 49.73, -0.37)
2:187455195		P>S	A:14	(13.72, 47.07, 3.16)
2:187455196		P>R	A:14	(13.72, 47.07, 3.16)
2:187455208		Y>C	A:18	(11.46, 44.30, 11.66)
2:187455216		F>L	A:21	(7.36, 48.18, 14.69)
2:187455222	COSM1742306	V>M	A:23	(2.39, 53.77, 11.19)
2:187455233	rs201076250	F>L	A:26	(3.87, 64.62, 6.95)
2:187455237		P>S	A:28	(2.21, 69.11, 5.95)
2:187455240		S>G	A:29	(1.35, 73.48, 6.92)
2:187455244		A>V	A:30	(3.58, 73.87, 3.77)
2:187455250		S>F	A:32	(-1.50, 70.39, -0.33)
2:187466749	rs142312022	R>W	A:33	(2.07, 66.71, -1.42)
2:187466750		R>Q	A:33	(2.07, 66.71, -1.42)
2:187466752		M>V	A:34	(-1.42, 64.53, 2.74)
2:187466773		P>S	A:41	(13.30, 49.46, 12.97)
2:187466793		Q>H	A:47	(24.52, 55.83, 9.69)
2:187466794	rs376272954	P>A	A:48	(29.36, 55.86, 9.34)
2:187466795		P>L	A:48	(29.36, 55.86, 9.34)
2:187466806		E>Q	A:52	(20.39, 46.74, 11.69)
2:187466825		K>R	A:58	(8.54, 60.96, 3.13)
2:187466843	rs150221000	T>I	A:64	(4.26, 56.71, -7.27)
2:187466845	rs199804238	R>C	A:65	(1.82, 53.81, -4.27)
2:187466848	rs200516634 COSM4089526 COSM4089527	R>W	A:66	(9.52, 57.13, -4.31)
2:187466849	rs201909609	R>Q	A:66	(9.52, 57.13, -4.31)
2:187487069		N>S	A:77	(29.25, 56.45, 16.74)
2:187487076	rs200368244	D>E	A:79	(34.17, 59.77, 19.66)
2:187487080		A>S	A:81	(37.90, 59.33, 22.72)
2:187487092		P>A	A:85	(33.09, 54.97, 21.53)
2:187487129	rs559990234	S>F	A:97	(8.72, 55.55, 17.35)
2:187487131		V>M	A:98	(6.61, 57.56, 14.23)
2:187487135		R>K	A:99	(3.54, 59.45, 16.64)
2:187487138		S>L	A:100	(3.24, 63.88, 13.14)
2:187487146		D>Y	A:103	(5.33, 71.00, 9.43)
2:187490246		R>Q	A:122	(27.31, 49.29, 25.09)
2:187490255		V>A	A:125	(19.30, 56.05, 27.16)
2:187490261		T>K	A:127	(17.40, 58.95, 21.12)
2:187490287	rs148135826	T>A	A:136	(17.36, 68.14, 12.89)
2:187490293		E>Q	A:138	(19.40, 64.67, 19.78)
2:187490308		R>G	A:143	(21.62, 61.74, 26.08)
2:187490309	rs370978233	R>K	A:143	(21.62, 61.74, 26.08)
2:187495526		D>Y	A:146	(20.66, 59.86, 36.62)
2:187495532	rs201182344	D>N	A:148	(23.56, 53.57, 36.22)
2:187495583	rs558224721	K>E	A:165	(-4.47, 70.53, 21.50)
2:187498065	rs202112395	V>I	A:169	(6.36, 65.72, 23.66)
2:187498071		L>V	A:171	(8.79, 60.24, 26.26)
2:187500817		I>V	A:184	(9.55, 62.65, 30.13)
2:187500821		S>L	A:185	(6.64, 66.35, 29.03)
2:187500841	rs200647242	V>I	A:192	(13.97, 73.47, 19.14)
2:187500848		K>R	A:194	(16.70, 75.11, 25.41)
2:187500853		D>N	A:196	(23.82, 72.58, 22.41)
2:187500869	rs367683819	S>N	A:201	(22.95, 66.58, 29.17)
2:187500873		I>M	A:202	(19.85, 69.31, 27.07)
2:187500884		N>T	A:206	(8.64, 74.34, 30.98)
2:187500899	rs376680231	R>Q	A:211	(8.60, 61.81, 41.50)
2:187500905		A>V	A:213	(9.71, 55.07, 43.68)
2:187500914		I>N	A:216	(7.02, 47.47, 45.39)
2:187500934	COSM375718	G>R	A:223	(5.78, 53.63, 29.04)
2:187501798		S>F	A:225	(2.01, 52.73, 26.35)
2:187501806	rs377471624 COSM4089530 COSM4089531	V>L	A:228	(-3.04, 62.04, 24.66)
2:187501818		N>D	A:232	(-9.45, 67.46, 33.55)
2:187501819	rs184114187	N>S	A:232	(-9.45, 67.46, 33.55)
2:187503018	rs200557809	V>I	A:243	(1.92, 49.89, 33.65)
2:187503148		D>N	A:257	(-2.36, 66.70, 35.11)
2:187503160		M>V	A:261	(3.06, 64.70, 35.73)
2:187503161		M>T	A:261	(3.06, 64.70, 35.73)
2:187503176		N>S	A:266	(-5.30, 54.43, 38.49)
2:187503184	rs199654707	G>S	A:269	(-6.20, 44.39, 35.92)
2:187503187	rs201930300	E>K	A:270	(-9.46, 41.71, 36.52)
2:187505644		M>I	A:272	(-1.70, 37.65, 36.59)
2:187505664		S>F	A:279	(-2.42, 49.04, 24.18)
2:187505667		V>E	A:280	(-3.06, 52.91, 25.15)
2:187505672	rs200935847	A>S	A:282	(-7.80, 58.26, 23.27)
2:187505681		I>V	A:285	(-16.66, 56.36, 21.03)
2:187505684	COSM1669583	N>D	A:286	(-20.06, 58.76, 23.28)
2:187505694	rs575373090	D>G	A:289	(-17.29, 66.50, 23.71)
2:187506114		Y>N	A:290	(-16.64, 64.36, 28.33)
2:187506118		A>V	A:291	(-12.44, 61.14, 26.35)
2:187506129		I>F	A:295	(-6.92, 49.37, 28.01)
2:187506133		G>V	A:296	(-4.73, 46.32, 26.08)
2:187506136		A>V	A:297	(-4.93, 42.62, 26.80)
2:187506147		M>V	A:301	(-6.73, 33.70, 29.54)
2:187506150		D>Y	A:302	(-11.68, 33.91, 27.64)
2:187506187	COSM305542	Q>L	A:314	(-9.88, 41.77, 27.32)
2:187506189		V>F	A:315	(-10.23, 45.63, 24.83)
2:187506205		Q>L	A:320	(-14.96, 60.63, 30.47)
2:187506216		G>R	A:324	(-15.24, 60.90, 36.91)
2:187506224		F>L	A:326	(-13.87, 56.43, 33.79)
2:187506256	rs146613742	F>S	A:337	(-2.80, 31.52, 20.81)
2:187506258		A>T	A:338	(-4.55, 36.54, 17.95)
2:187506262		R>Q	A:339	(-0.93, 38.12, 20.72)
2:187506268		G>D	A:341	(-5.11, 44.30, 21.44)
2:187506273		A>T	A:343	(-3.66, 47.55, 18.37)
2:187506276	rs200664669	I>V	A:344	(-6.15, 50.34, 20.18)
2:187506282	rs373402521	P>S	A:346	(-8.04, 55.88, 16.77)
2:187506289		G>E	A:348	(-12.82, 58.70, 13.92)
2:187506307	rs537982004	G>D	A:354	(-21.39, 61.32, 14.44)
2:187511418		A>T	A:359	(-9.31, 49.90, 15.39)
2:187511419	rs145167954	A>V	A:359	(-9.31, 49.90, 15.39)
2:187511446		D>V	A:368	(-2.67, 31.01, 7.07)
2:187511460	rs569411702	V>I	A:373	(-8.10, 44.63, 11.45)
2:187511464		Y>C	A:374	(-11.29, 42.53, 14.21)
2:187511466	rs3738918	I>V	A:375	(-13.62, 48.05, 12.15)
2:187511472		N>D	A:377	(-18.81, 51.49, 14.35)
2:187511479	rs143468341	R>I	A:379	(-23.69, 52.80, 19.60)
2:187511484		T>A	A:381	(-24.85, 53.72, 23.58)
2:187511487	rs370277214	G>S	A:382	(-21.16, 53.67, 22.69)
2:187511492		L>F	A:383	(-18.22, 50.63, 21.11)
2:187511496	rs543038574 COSM1727762 COSM1403924	A>S	A:385	(-19.33, 45.20, 20.10)
2:187511497		A>V	A:385	(-19.33, 45.20, 20.10)
2:187511499		V>I	A:386	(-20.59, 44.02, 16.63)
2:187511502	rs201689701	P>A	A:387	(-17.55, 43.73, 14.45)
2:187511506		S>F	A:388	(-18.43, 46.50, 10.74)
2:187511536		R>Q	A:398	(9.83, 35.39, 3.64)
2:187511560	rs201332846	Y>C	A:406	(2.75, 45.07, 16.38)
2:187511584		I>T	A:414	(-4.85, 60.86, 2.43)
2:187511590		K>R	A:416	(-8.85, 66.10, 0.43)
2:187511595		G>R	A:418	(-14.46, 63.01, 3.88)
2:187511602		P>L	A:420	(-11.51, 59.01, 7.59)
2:187514582	rs200462398	A>V	A:426	(3.45, 44.42, 8.19)
2:187514585		F>S	A:427	(6.88, 43.75, 11.77)
2:187514597		R>Q	A:431	(4.57, 44.64, 2.68)
2:187514599		A>T	A:432	(2.46, 49.08, 4.35)
2:187516716		P>S	A:439	(-18.37, 57.07, 0.01)
2:187516717		P>L	A:439	(-18.37, 57.07, 0.01)
2:187516723	rs201241523	I>T	A:441	(-25.21, 56.48, 0.06)
2:187516732		N>S	A:444	(-34.89, 56.68, 2.18)
2:187516735	rs202007073	A>D	A:445	(-37.78, 53.96, -0.27)
2:187516737	rs200310686	G>S	A:446	(-40.93, 54.06, -2.07)
2:187516741		L>R	A:447	(-44.03, 51.10, -2.50)
2:187516743		E>K	A:448	(-47.75, 54.20, -2.28)
2:187516773	rs142779223	N>Y	A:458	(-63.41, 47.83, -11.55)
2:187516774	rs200705825	N>S	A:458	(-63.41, 47.83, -11.55)
2:187516795	rs147403786	G>A	A:465	(-54.45, 43.72, -27.85)
2:187516815	rs149953343	C>R	A:472	(-56.29, 48.07, -12.82)
2:187519387		R>W	A:476	(-45.98, 55.80, -6.51)
2:187519403		A>E	A:481	(-30.40, 59.97, -2.15)
2:187519406		D>G	A:482	(-27.82, 62.42, 0.26)
2:187519408	rs202013444	G>S	A:483	(-24.25, 62.02, 1.08)
2:187519420		L>I	A:487	(-20.59, 61.77, -3.50)
2:187520981		Q>H	A:494	(-31.03, 47.83, -11.41)
2:187521010	rs373532184 COSM1194647	Q>R	A:504	(-44.39, 32.78, -6.90)
2:187521025		R>Q	A:509	(-46.90, 33.94, -12.65)
2:187521034		L>P	A:512	(-49.72, 40.30, -14.27)
2:187521048		R>G	A:517	(-49.14, 39.48, -20.47)
2:187521051	rs2230615	S>A	A:518	(-44.96, 39.76, -15.80)
2:187521057	rs200088164	S>G	A:520	(-41.33, 40.58, -13.50)
2:187521064	rs146565475	S>F	A:522	(-36.72, 45.60, -14.25)
2:187521072	rs200277128	M>V	A:525	(-33.84, 54.91, -11.52)
2:187521078	rs201190961	I>V	A:527	(-31.50, 59.57, -8.27)
2:187521085	rs567294324 COSM1403929	R>M	A:529	(-26.20, 64.04, -4.13)
2:187521087	rs199845024	G>R	A:530	(-31.04, 64.93, -2.02)
2:187521091	rs185792013	G>V	A:531	(-34.66, 65.69, -2.46)
2:187521097		M>T	A:533	(-38.45, 61.17, -3.84)
2:187521102		C>G	A:535	(-40.94, 58.78, -8.95)
2:187521117	rs201670713	A>T	A:540	(-51.08, 46.43, -12.68)
2:187521118	rs199670325 COSM718923	A>V	A:540	(-51.08, 46.43, -12.68)
2:187521120	rs201927835	Y>D	A:541	(-53.10, 42.62, -15.50)
2:187521126	rs571276917	R>W	A:543	(-54.14, 36.18, -13.89)
2:187521127		R>Q	A:543	(-54.14, 36.18, -13.89)
2:187523772		S>F	A:546	(-61.16, 32.02, -13.96)
2:187523804		I>V	A:557	(-46.34, 44.69, -4.14)
2:187523810		M>V	A:559	(-39.00, 47.76, -4.24)
2:187523819	rs200949549 COSM4089536 COSM4089537	R>W	A:562	(-29.36, 45.76, -7.76)
2:187523820	rs201898547	R>Q	A:562	(-29.36, 45.76, -7.76)
2:187523826	rs200210960	D>G	A:564	(-24.91, 50.30, -10.98)
2:187523844		D>G	A:570	(-13.30, 57.63, -8.16)
2:187523850	rs375197365	T>R	A:572	(-9.12, 56.34, -8.02)
2:187523853		G>V	A:573	(-12.04, 53.63, -7.86)
2:187523861	rs367819287	P>S	A:576	(-19.71, 54.07, -3.57)
2:187523867	COSM1559551	L>V	A:578	(-25.50, 51.45, 0.81)
2:187523876	rs200254694	F>L	A:581	(-29.47, 49.33, 10.38)
2:187523880	rs150474737	T>M	A:582	(-30.21, 50.41, 4.89)
2:187523898		R>Q	A:588	(-46.22, 48.80, 0.88)
2:187528496	rs536289285	A>V	A:590	(-53.00, 44.21, -1.98)
2:187528519	rs554519341	E>K	A:598	(-73.60, 47.31, 1.27)
2:187528523		D>G	A:599	(-70.20, 49.59, 1.50)
2:187528532		C>Y	A:602	(-64.12, 46.55, 5.29)
2:187528547	rs137918565	E>A	A:607	(-63.39, 44.19, 20.98)
2:187528553		S>Y	A:609	(-59.53, 41.98, 26.75)
2:187529238	rs201180647	Y>C	A:618	(-44.09, 39.69, 45.13)
2:187529240		I>V	A:619	(-40.18, 44.81, 44.73)
2:187529241	rs200809220	I>T	A:619	(-40.18, 44.81, 44.73)
2:187529244	COSM572548	G>A	A:620	(-36.37, 42.29, 43.35)
2:187529250	rs376843234	D>G	A:622	(-36.87, 38.14, 37.86)
2:187529279		Q>E	A:632	(-63.37, 40.33, 19.91)
2:187529289		G>E	A:635	(-66.95, 42.93, 12.12)
2:187529315	rs138771382	I>V	A:644	(-49.91, 46.64, 19.50)
2:187529316		I>T	A:644	(-49.91, 46.64, 19.50)
2:187529318		V>I	A:645	(-48.42, 44.83, 23.73)
2:187529348	rs200130364	G>R	A:655	(-43.50, 34.32, 24.94)
2:187529853	rs201558849	A>P	A:662	(-56.89, 26.37, 24.65)
2:187529858		L>F	A:663	(-54.44, 29.48, 24.54)
2:187529866		L>H	A:666	(-50.51, 34.22, 18.40)
2:187529868		S>T	A:667	(-46.93, 35.22, 15.44)
2:187529889		N>D	A:674	(-39.36, 54.76, 17.56)
2:187529898		R>C	A:677	(-39.73, 48.31, 25.23)
2:187529899	rs554897868	R>H	A:677	(-39.73, 48.31, 25.23)
2:187529907		V>I	A:680	(-46.21, 42.85, 17.27)
2:187529908		V>A	A:680	(-46.21, 42.85, 17.27)
2:187529910	COSM1631655	C>R	A:681	(-49.21, 40.07, 17.53)
2:187529916		L>F	A:683	(-54.57, 39.08, 15.02)
2:187529928	rs199555610	M>V	A:687	(-59.17, 39.53, 12.04)
2:187529929		M>T	A:687	(-59.17, 39.53, 12.04)
2:187529934	COSM1013847 COSM331980	A>S	A:689	(-65.59, 38.11, 10.68)
2:187531431	rs202242205	L>F	A:693	(-58.31, 35.09, 19.21)
2:187531435		L>S	A:694	(-57.95, 33.42, 24.00)
2:187531446	COSM3575188 COSM3575189	R>C	A:698	(-44.95, 32.89, 28.80)
2:187531447	rs554793668	R>H	A:698	(-44.95, 32.89, 28.80)
2:187531459		H>R	A:702	(-36.40, 42.17, 34.99)
2:187531474		M>T	A:707	(-40.64, 54.98, 45.54)
2:187531477	rs201172979	D>A	A:708	(-43.09, 52.68, 41.87)
2:187531882		N>I	A:721	(-58.65, 48.82, 7.35)
2:187531890		D>N	A:724	(-63.42, 51.54, 11.99)
2:187531901		S>R	A:727	(-58.93, 49.35, 19.19)
2:187531912	rs150579951	S>F	A:731	(-54.91, 49.82, 30.42)
2:187532403	COSM718920	S>L	A:748	(-22.54, 27.67, 70.20)
2:187532408	rs200169203	P>S	A:750	(-18.54, 25.47, 72.24)
2:187532415	rs199914502	H>R	A:752	(-20.16, 20.88, 74.07)
2:187532417	rs2230616	V>I	A:753	(-18.75, 22.74, 78.41)
2:187532418	rs200258394	V>A	A:753	(-18.75, 22.74, 78.41)
2:187532427		P>L	A:756	(-13.75, 18.95, 85.01)
2:187532437		N>K	A:759	(-5.13, 22.44, 83.53)
2:187532438		W>G	A:760	(-10.32, 26.28, 87.03)
2:187532445	rs201916887	H>R	A:762	(-10.07, 29.94, 92.33)
2:187532456	rs201122594	P>T	A:766	(-9.24, 37.21, 87.86)
2:187532465	rs202170056 COSM3962072 COSM3962073	E>K	A:769	(-9.40, 34.36, 78.22)
2:187532474	rs193173970	V>I	A:772	(-12.31, 32.54, 83.84)
2:187532477		G>R	A:773	(-12.34, 30.00, 81.02)
2:187532489		Q>E	A:777	(-18.05, 32.46, 69.92)
2:187532492		H>Y	A:778	(-23.21, 32.59, 71.59)
2:187532499	COSM1669584	Y>C	A:780	(-27.06, 35.40, 67.68)
2:187533498		N>D	A:785	(-33.41, 35.40, 52.18)
2:187533499	rs61757099	N>S	A:785	(-33.41, 35.40, 52.18)
2:187533519		K>E	A:792	(-34.58, 51.29, 59.61)
2:187533544		P>R	A:800	(-27.28, 34.60, 80.04)
2:187533551		K>N	A:802	(-25.20, 37.11, 87.06)
2:187533553	rs199789114	Y>C	A:803	(-28.99, 31.39, 89.10)
2:187533561	rs199591827	N>D	A:806	(-23.45, 33.45, 90.30)
2:187533576		I>V	A:811	(-19.69, 39.27, 77.56)
2:187533586	rs142978189	Y>C	A:814	(-20.11, 43.71, 71.02)
2:187533619	rs372469580	D>V	A:825	(-27.74, 47.23, 79.27)
2:187533622	rs377142689	M>T	A:826	(-24.60, 45.85, 81.45)
2:187533627		I>F	A:828	(-18.99, 44.93, 78.00)
2:187534531		I>T	A:869	(-31.01, 19.63, 82.00)
2:187540338		G>E	A:875	(-36.26, 34.55, 83.33)
2:187540374	rs201617888	G>E	A:887	(-30.03, 48.65, 58.13)
2:187540377		R>T	A:888	(-31.12, 49.18, 52.31)
2:187540398		A>V	A:895	(-26.31, 40.83, 59.98)
2:187540409	rs146319338	V>I	A:899	(-20.94, 37.18, 71.45)
2:187540414	rs370683564	K>N	A:900	(-15.23, 36.34, 72.73)
2:187540427		T>A	A:905	(-15.54, 27.81, 86.09)
2:187540437		F>S	A:908	(-20.82, 26.31, 86.73)
2:187540444	rs145339092	N>K	A:910	(-18.29, 26.24, 94.47)
2:187540550		E>K	A:912	(-25.00, 25.85, 96.49)
2:187540553	rs376024712	N>Y	A:913	(-23.48, 21.44, 95.74)
2:187540562		H>D	A:916	(-26.08, 20.12, 89.48)
2:187540563		H>L	A:916	(-26.08, 20.12, 89.48)
2:187540565	rs199524190	S>T	A:917	(-26.90, 19.76, 84.42)
2:187540569		Y>F	A:918	(-26.70, 24.08, 85.28)
2:187540581		S>L	A:922	(-29.38, 32.87, 74.38)
2:187540589		S>A	A:925	(-35.31, 39.28, 68.60)
2:187540596		N>S	A:927	(-38.98, 44.32, 64.35)
2:187540603		I>M	A:929	(-38.99, 49.18, 61.63)
2:187540628		I>V	A:938	(-46.03, 47.67, 54.82)
2:187540629		I>T	A:938	(-46.03, 47.67, 54.82)
2:187540636	rs567843082	D>E	A:940	(-43.92, 45.15, 60.69)
2:187540644		N>S	A:943	(-38.99, 35.64, 64.17)
2:187540646		S>A	A:944	(-37.03, 34.28, 67.29)
2:187541540		V>I	A:947	(-28.28, 29.90, 71.49)
2:187541544		T>I	A:948	(-27.95, 26.46, 73.87)
2:187541549		N>D	A:950	(-25.42, 22.44, 77.19)
2:187541565	rs375077965	I>S	A:955	(-16.85, 12.81, 85.38)
2:187541574	rs200757637	A>V	A:958	(-22.08, 7.39, 90.70)
2:187541577	rs373527978	P>L	A:959	(-22.88, 5.03, 92.07)

4G1M.A | ITGAV.

4G1M.A | ITGAV

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:187501821	COSM3713562	G>S	A:233	(-11.48, 70.48, 32.90)
2:187503163	COSM3787951	S>T	A:262	(-0.83, 64.90, 38.87)
2:187506172	COSM1403916	L>P	A:309	(-8.53, 29.20, 30.49)
2:187511496	COSM1727762	A>S	A:385	(-19.33, 45.20, 20.10)
2:187529354	COSM1614034	V>F	A:657	(-48.37, 30.44, 25.71)
2:187531446	COSM3575188	R>C	A:698	(-44.95, 32.89, 28.80)
2:187531954	COSM1559552	R>K	A:745	(-29.42, 30.73, 61.44)
2:187532499	COSM1669584	Y>C	A:780	(-27.06, 35.40, 67.68)
2:187540572	COSM173093	S>Y	A:919	(-28.99, 25.15, 79.64)