General Structure Information
| PDB ID | 2xsn |
| HGNC Gene Label(s) | TH |
| Structure Name | crystal structure of human tyrosine hydroxylase catalytic domain |
| Resolution | 2.68Å |
| Reference | AUTH J.R.C.MUNIZ,C.D.O.COOPER,W.W.YUE,E.KRYSZTOFINSKA,AUTH 2 F.VON DELFT,S.KNAPP,O.GILEADI,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 J.WEIGELT,C.BOUNTRA,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTICTITL 2 DOMAINREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 335 |
| Number Of SNVs | 65 |
| Number Of Permutations | 13703 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.285 |
| p-value | 0.081 |
ClinVar
| Number Of Residues | 335 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1499 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.071 |
| p-value | 0.571 |
COSMIC
| Number Of Residues | 335 |
| Number Of SNVs | 3 |
| Number Of Permutations | 27 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.496 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 65 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.049 |
| p-value | 0.363 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 65 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.25 |
| p-value | 0.314 |