General Structure Information
| PDB ID | 3ewu |
| HGNC Gene Label(s) | UMPS |
| Structure Name | d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct |
| Resolution | 1.6Å |
| Reference | AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 256 |
| Number Of SNVs | 56 |
| Number Of Permutations | 16789 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.09 |
| p-value | 0.612 |
COSMIC
| Number Of Residues | 256 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 56 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.368 |
| p-value | 0.415 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
