General Structure Information
| PDB ID | 1rrj |
| HGNC Gene Label(s) | TOP1 |
| Structure Name | structural mechanisms of camptothecin resistance by mutations in human topoisomerase i |
| Resolution | 2.3Å |
| Reference | AUTH J.E.CHRENCIK,B.L.STAKER,A.B.BURGIN,P.POURQUIER,AUTH 2 Y.POMMIER,L.STEWART,M.R.REDINBOTITL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY HUMANTITL 2 TOPOISOMERASE I MUTATIONSREF J.MOL.BIOL. V. 339 773 2004REFN ISSN 0022-2836PMID 15165849DOI 10.1016/J.JMB.2004.03.077 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 564 |
| Number Of SNVs | 55 |
| Number Of Permutations | 46374 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.203 |
| p-value | 0.0 |
ClinVar
| Number Of Residues | 564 |
| Number Of SNVs | 3 |
| Number Of Permutations | 430 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 1.0 |
| p-value | 0.234 |
COSMIC
| Number Of Residues | 564 |
| Number Of SNVs | 4 |
| Number Of Permutations | 111 |
| Optimal Distance Threshold | 41.0 |
| K Statistic | 0.167 |
| p-value | 0.213 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 0.779 |
| p-value | 0.189 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | -0.313 |
| p-value | 0.482 |