General Structure Information
| PDB ID | 3r01 |
| HGNC Gene Label(s) | PIM1 |
| Structure Name | the discovery of novel benzofuran-2-carboxylic acids as potent pim-1 inhibitors |
| Resolution | 2.6Å |
| Reference | AUTH Y.XIANG,B.HIRTH,G.ASMUSSEN,H.P.BIEMANN,K.A.BISHOP,A.GOOD,AUTH 2 M.FITZGERALD,T.GLADYSHEVA,A.JAIN,K.JANCSICS,J.LIU,M.METZ,AUTH 3 A.PAPOULIS,R.SKERLJ,J.D.STEPP,R.R.WEITITL THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS ASTITL 2 POTENT PIM-1 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 21 3050 2011REFN ISSN 0960-894XPMID 21507633DOI 10.1016/J.BMCL.2011.03.030 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 274 |
| Number Of SNVs | 55 |
| Number Of Permutations | 7292 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.084 |
| p-value | 0.129 |
COSMIC
| Number Of Residues | 274 |
| Number Of SNVs | 12 |
| Number Of Permutations | 8746 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.015 |
| p-value | 0.955 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | -0.036 |
| p-value | 0.692 |