General Structure Information
| PDB ID | 1dig |
| HGNC Gene Label(s) | MTHFD1 |
| Structure Name | human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly374571 |
| Resolution | 2.2Å |
| Reference | AUTH A.SCHMIDT,H.WU,R.E.MACKENZIE,V.J.CHEN,J.R.BEWLY,AUTH 2 J.E.RAY,J.E.TOTH,M.CYGLERTITL STRUCTURES OF THREE INHIBITOR COMPLEXES PROVIDETITL 2 INSIGHT INTO THE REACTION MECHANISM OF THE HUMANTITL 3 METHYLENETETRAHYDROFOLATETITL 4 DEHYDROGENASE/CYCLOHYDROLASE.REF BIOCHEMISTRY V. 39 6325 2000REFN ISSN 0006-2960PMID 10828945DOI 10.1021/BI992734Y |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 295 |
| Number Of SNVs | 56 |
| Number Of Permutations | 9118 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.051 |
| p-value | 0.801 |