General Structure Information
| PDB ID | 3rhk |
| HGNC Gene Label(s) | MET |
| Structure Name | crystal structure of the catalytic domain of c-met kinase in complex with arq 197 |
| Resolution | 1.94Å |
| Reference | AUTH S.EATHIRAJ,R.PALMA,E.VOLCKOVA,M.HIRSCHI,D.S.FRANCE,AUTH 2 M.A.ASHWELL,T.C.CHANTITL DISCOVERY OF A NOVEL MODE OF PROTEIN KINASE INHIBITIONTITL 2 CHARACTERIZED BY THE MECHANISM OF INHIBITION OF HUMANTITL 3 MESENCHYMAL-EPITHELIAL TRANSITION FACTOR (C-MET) PROTEINTITL 4 AUTOPHOSPHORYLATION BY ARQ 197.REF J.BIOL.CHEM. V. 286 20666 2011REFN ISSN 0021-9258PMID 21454604DOI 10.1074/JBC.M110.213801 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 299 |
| Number Of SNVs | 46 |
| Number Of Permutations | 22198 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.175 |
| p-value | 0.118 |
ClinVar
| Number Of Residues | 299 |
| Number Of SNVs | 11 |
| Number Of Permutations | 5152 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.091 |
| p-value | 0.251 |
COSMIC
| Number Of Residues | 299 |
| Number Of SNVs | 15 |
| Number Of Permutations | 3012 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.162 |
| p-value | 0.102 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of ClinVar SNVs | 10 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.08 |
| p-value | 0.359 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.139 |
| p-value | 0.636 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
