General Structure Information
| PDB ID | 1u3t |
| HGNC Gene Label(s) | ADH1A |
| Structure Name | crystal structure of human alcohol dehydrogenase alpha- alpha isoform complexed with n-cyclopentyl-n- cyclobutylformamide determined to 2.5 angstrom resolution |
| Resolution | 2.49Å |
| Reference | AUTH B.J.GIBBONS,T.D.HURLEYTITL STRUCTURE OF THREE CLASS I HUMAN ALCOHOLTITL 2 DEHYDROGENASES COMPLEXED WITH ISOENZYME SPECIFICTITL 3 FORMAMIDE INHIBITORSREF BIOCHEMISTRY V. 43 12555 2004REFN ISSN 0006-2960PMID 15449945DOI 10.1021/BI0489107 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 374 |
| Number Of SNVs | 100 |
| Number Of Permutations | 45127 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.024 |
| p-value | 0.905 |
COSMIC
| Number Of Residues | 374 |
| Number Of SNVs | 11 |
| Number Of Permutations | 3100 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.018 |
| p-value | 0.841 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 100 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.056 |
| p-value | 0.691 |