General Structure Information
| PDB ID | 2r4s |
| HGNC Gene Label(s) | ADRB2 |
| Structure Name | crystal structure of the human beta2 adrenoceptor |
| Resolution | 3.4Å |
| Reference | AUTH S.G.F.RASMUSSEN,H.J.CHOI,D.M.ROSENBAUM,T.S.KOBILKA,AUTH 2 F.S.THIAN,P.C.EDWARDS,M.BURGHAMMER,V.R.RATNALA,R.SANISHVILI,AUTH 3 R.F.FISCHETTI,G.F.SCHERTLER,W.I.WEIS,B.K.KOBILKATITL CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENERGICTITL 2 G-PROTEIN-COUPLED RECEPTOR.REF NATURE V. 450 383 2007REFN ISSN 0028-0836PMID 17952055DOI 10.1038/NATURE06325 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 216 |
| Number Of SNVs | 40 |
| Number Of Permutations | 7148 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.033 |
| p-value | 0.285 |
COSMIC
| Number Of Residues | 216 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.256 |
| p-value | 0.783 |