General Structure Information
| PDB ID | 1t2f |
| HGNC Gene Label(s) | LDHB |
| Structure Name | human b lactate dehydrogenase complexed with nad+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid |
| Resolution | 3.0Å |
| Reference | AUTH A.CAMERON,J.READ,R.TRANTER,V.J.WINTER,R.B.SESSIONS,AUTH 2 R.L.BRADY,L.VIVAS,A.EASTON,H.KENDRICK,S.L.CROFT,AUTH 3 D.BARROS,J.L.LAVANDERA,J.J.MARTIN,F.RISCO,AUTH 4 S.GARCIA-OCHOA,F.J.GAMO,L.SANZ,L.LEON,J.R.RUIZ,AUTH 5 R.GABARRO,A.MALLO,F.G.DE LAS HERASTITL IDENTIFICATION AND ACTIVITY OF A SERIES OFTITL 2 AZOLE-BASED COMPOUNDS WITH LACTATETITL 3 DEHYDROGENASE-DIRECTED ANTI-MALARIAL ACTIVITY.REF J.BIOL.CHEM. V. 279 31429 2004REFN ISSN 0021-9258PMID 15117937DOI 10.1074/JBC.M402433200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 331 |
| Number Of SNVs | 75 |
| Number Of Permutations | 55841 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.107 |
| p-value | 0.203 |
ClinVar
| Number Of Residues | 331 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1241 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.0 |
| p-value | 0.041 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 75 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.505 |
| p-value | 0.022 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
