General Structure Information
| PDB ID | 2y5l |
| HGNC Gene Label(s) | FBP1 |
| Structure Name | orally active aminopyridines as inhibitors of tetrameric fructose 1,6-bisphosphatase |
| Resolution | 2.2Å |
| Reference | AUTH P.HEBEISEN,W.HAAP,B.KUHN,P.MOHR,H.P.WESSEL,U.ZUTTER,AUTH 2 S.KIRCHNER,A.RUF,J.BENZ,C.JOSEPH,R.ALVAREZ-SANCHEZ,M.GUBLER,AUTH 3 B.SCHOTT,A.BENARDEAU,E.TOZZO,E.KITASTITL ORALLY ACTIVE AMINOPYRIDINES AS INHIBITORS OF TETRAMERICTITL 2 FRUCTOSE-1,6-BISPHOSPHATASE.REF BIOORG.MED.CHEM.LETT. V. 21 3237 2011REFN ISSN 0960-894XPMID 21550236DOI 10.1016/J.BMCL.2011.04.044 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 318 |
| Number Of SNVs | 76 |
| Number Of Permutations | 40491 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.042 |
| p-value | 0.107 |
ClinVar
| Number Of Residues | 318 |
| Number Of SNVs | 7 |
| Number Of Permutations | 3525 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.238 |
| p-value | 0.054 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 76 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.15 |
| p-value | 0.119 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
