2OVA.A | C8G – ASTRID

2OVA.A | C8G

General Structure Information

PDB ID	2ova
HGNC Gene Label(s)	C8G
Structure Name	x-ray structure of human complement protein c8gamma y83w mutant
Resolution	1.5Å
Reference	AUTH B.CHISWELL,L.L.LOVELACE,C.BRANNEN,E.A.ORTLUND,AUTH 2 L.LEBIODA,J.M.SODETZTITL STRUCTURAL FEATURES OF THE LIGAND BINDING SITE ONTITL 2 HUMAN COMPLEMENT PROTEIN C8GAMMA: A MEMBER OF THETITL 3 LIPOCALIN FAMILYREF BIOCHIM.BIOPHYS.ACTA V.1774 637 2007REFN ISSN 0006-3002PMID 17452033DOI 10.1016/J.BBAPAP.2007.03.004

Variant Set Distributions

ExAC Variants

Number Of Residues	164
Number Of SNVs	46
Number Of Permutations	3975
Optimal Distance Threshold	6.0
K Statistic	0.019
p-value	0.488

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:139839878	rs537751602	I>V	A:16	(9.39, 24.13, 23.70)
9:139839890		A>T	A:20	(8.09, 29.19, 12.27)
9:139839903		A>V	A:24	(19.30, 32.33, 10.16)
9:139840088		F>L	A:27	(18.65, 35.10, 14.94)
9:139840092	rs566621606	G>R	A:29	(23.98, 39.21, 14.44)
9:139840107		V>M	A:34	(18.00, 41.16, 28.81)
9:139840113	rs376788659	V>L	A:36	(18.13, 34.40, 32.52)
9:139840122	rs140338586	A>T	A:39	(16.84, 27.24, 38.90)
9:139840128		R>C	A:41	(23.12, 31.01, 40.16)
9:139840129		R>H	A:41	(23.12, 31.01, 40.16)
9:139840153	rs17614	R>Q	A:49	(28.48, 40.55, 38.97)
9:139840155		A>P	A:50	(26.04, 39.52, 35.65)
9:139840156		A>V	A:50	(26.04, 39.52, 35.65)
9:139840162	rs574887058	A>V	A:52	(27.88, 42.23, 29.67)
9:139840174		H>R	A:56	(28.52, 38.87, 17.34)
9:139840182		P>S	A:59	(24.80, 32.09, 9.15)
9:139840192		T>I	A:62	(21.95, 24.04, 8.94)
9:139840216	rs145738215	R>Q	A:70	(30.61, 36.70, 28.26)
9:139840404	rs374701186	R>H	A:80	(35.54, 31.74, 18.48)
9:139840424		G>R	A:87	(16.38, 19.38, 12.29)
9:139840433		G>S	A:90	(15.28, 26.10, 15.77)
9:139840434		G>D	A:90	(15.28, 26.10, 15.77)
9:139840436		R>C	A:91	(14.75, 22.22, 18.14)
9:139840437		R>H	A:91	(14.75, 22.22, 18.14)
9:139840545	rs576335345	A>T	A:99	(32.69, 21.22, 30.88)
9:139840549		R>Q	A:100	(29.72, 18.94, 33.17)
9:139840560	rs17613	H>N	A:104	(19.60, 20.45, 23.69)
9:139840572		A>T	A:108	(10.59, 30.20, 20.18)
9:139840578		T>A	A:110	(11.65, 35.97, 16.87)
9:139840579		T>I	A:110	(11.65, 35.97, 16.87)
9:139840588		Q>R	A:113	(13.14, 43.28, 13.20)
9:139840596	rs56188501	A>T	A:116	(14.50, 36.76, 21.40)
9:139840597	rs201923558	A>G	A:116	(14.50, 36.76, 21.40)
9:139840614	rs144007361	R>W	A:122	(21.97, 23.94, 30.57)
9:139840615		R>Q	A:122	(21.97, 23.94, 30.57)
9:139840618	rs369304536	A>V	A:123	(20.64, 18.44, 32.93)
9:139840644	rs527711843	A>T	A:132	(17.87, 42.33, 22.24)
9:139840919	rs553764725	R>C	A:133	(18.82, 42.73, 17.22)
9:139840922	rs145905325	S>P	A:134	(17.96, 47.35, 21.22)
9:139840931		V>M	A:137	(12.95, 45.90, 25.90)
9:139840937	rs373466029	D>N	A:139	(6.77, 47.48, 28.15)
9:139840941		S>L	A:140	(5.18, 43.65, 25.41)
9:139840952	rs369164564	G>R	A:144	(6.18, 38.05, 28.03)
9:139840961		Q>E	A:147	(3.42, 34.78, 31.07)
9:139840962		Q>R	A:147	(3.42, 34.78, 31.07)
9:139840964		R>W	A:148	(5.89, 32.62, 27.57)
9:139840965	rs562689598	R>Q	A:148	(5.89, 32.62, 27.57)
9:139840973		E>K	A:151	(3.86, 29.80, 30.92)
9:139840975		E>D	A:151	(3.86, 29.80, 30.92)
9:139840988	rs373343707	E>K	A:156	(10.04, 37.41, 38.71)
9:139840998		I>T	A:159	(14.07, 36.47, 36.53)
9:139841003	rs138632480	Y>H	A:161	(16.64, 41.37, 34.81)
9:139841010		P>L	A:163	(24.20, 44.09, 32.45)
9:139841018	rs376465412	G>S	A:166	(29.46, 47.40, 29.31)
9:139841108	rs564090191	C>R	A:168	(31.79, 43.93, 24.59)
9:139841120	rs533270288	D>H	A:172	(42.58, 40.06, 22.86)
9:139841121	rs144581740	D>G	A:172	(42.58, 40.06, 22.86)