General Structure Information
| PDB ID | 1igr |
| HGNC Gene Label(s) | IGF1R |
| Structure Name | type 1 insulin-like growth factor receptor (domains 1-3) |
| Resolution | 2.6Å |
| Reference | AUTH T.P.GARRETT,N.M.MCKERN,M.LOU,M.J.FRENKEL,J.D.BENTLEY,AUTH 2 G.O.LOVRECZ,T.C.ELLEMAN,L.J.COSGROVE,C.W.WARDTITL CRYSTAL STRUCTURE OF THE FIRST THREE DOMAINS OF THE TYPE-1TITL 2 INSULIN-LIKE GROWTH FACTOR RECEPTOR.REF NATURE V. 394 395 1998REFN ISSN 0028-0836PMID 9690478DOI 10.1038/28668 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 459 |
| Number Of SNVs | 89 |
| Number Of Permutations | 31522 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.287 |
| p-value | 0.003 |
COSMIC
| Number Of Residues | 459 |
| Number Of SNVs | 13 |
| Number Of Permutations | 5114 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.103 |
| p-value | 0.652 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 89 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.062 |
| p-value | 0.581 |