2HYW.A | ANXA2

General Structure Information

PDB ID	2hyw
HGNC Gene Label(s)	ANXA2
Structure Name	human annexin a2 with calcium bound
Resolution	2.1Å
Reference	AUTH C.SHAO,F.ZHANG,M.M.KEMP,R.J.LINHARDT,D.M.WAISMAN,AUTH 2 J.F.HEAD,B.A.SEATONTITL CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENTTITL 2 HEPARIN BINDING TO ANNEXIN A2.REF J.BIOL.CHEM. V. 281 31689 2006REFN ISSN 0021-9258PMID 16882661DOI 10.1074/JBC.M604502200

Variant Set Distributions

ExAC Variants

Number Of Residues	308
Number Of SNVs	77
Number Of Permutations	14148
Optimal Distance Threshold	22.0
K Statistic	0.387
p-value	0.581

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:60674586		A>T	A:34	(67.85, 15.21, 71.27)
15:60674579		R>Q	A:36	(68.52, 12.87, 77.46)
15:60674580		R>W	A:36	(68.52, 12.87, 77.46)
15:60674564	rs538028221	I>T	A:41	(66.37, 5.37, 71.35)
15:60674565		I>L	A:41	(66.37, 5.37, 71.35)
15:60674553		I>V	A:45	(68.09, -0.59, 70.50)
15:60674550		K>E	A:46	(72.04, -1.85, 72.87)
15:60656719		V>G	A:50	(64.38, -4.76, 71.88)
15:60656674		A>V	A:65	(61.11, 17.82, 63.67)
15:60656666		Q>E	A:68	(64.29, 14.64, 61.71)
15:60656651	COSM1373840	A>T	A:73	(71.99, 13.01, 67.61)
15:60656628		K>N	A:80	(74.49, 3.36, 63.43)
15:60653228	rs147297902	A>V	A:89	(65.51, -3.73, 65.90)
15:60653226	rs377255137	L>I	A:90	(62.13, -2.94, 64.87)
15:60653207	rs144035126	T>M	A:96	(55.98, 0.06, 59.08)
15:60653205	rs17845226	V>L	A:97	(54.86, 2.84, 62.22)
15:60653183	rs577274556	T>R	A:104	(60.23, 13.88, 55.95)
15:60653173		Q>H	A:107	(61.29, 11.76, 52.93)
15:60653165		A>V	A:110	(57.58, 9.61, 48.04)
15:60653166	rs373508768	A>T	A:110	(57.58, 9.61, 48.04)
15:60653143		M>I	A:117	(54.13, 3.21, 41.00)
15:60649426	COSM73684	T>S	A:122	(49.04, -0.03, 40.14)
15:60649407		I>T	A:128	(43.89, 7.78, 44.43)
15:60649393		S>P	A:133	(45.04, 14.56, 49.74)
15:60649390		R>G	A:134	(48.56, 14.80, 50.21)
15:60649383	rs138420486	N>I	A:136	(49.65, 22.94, 45.83)
15:60649366		I>V	A:142	(56.16, 15.29, 47.08)
15:60649345		M>V	A:149	(64.56, 9.89, 47.01)
15:60648194		Y>C	A:150	(62.99, 7.49, 44.23)
15:60648171		I>V	A:158	(52.34, 8.88, 37.26)
15:60648164	rs138727673	S>L	A:160	(54.69, 4.82, 33.18)
15:60648165		S>A	A:160	(54.69, 4.82, 33.18)
15:60648152		G>D	A:164	(44.15, 7.74, 30.33)
15:60648143	rs548464218	R>H	A:167	(48.01, 8.64, 31.89)
15:60648144	rs567083246	R>C	A:167	(48.01, 8.64, 31.89)
15:60648139		K>N	A:168	(44.31, 12.71, 31.31)
15:60648133	rs368222718	M>I	A:170	(46.59, 11.11, 38.95)
15:60648134		M>T	A:170	(46.59, 11.11, 38.95)
15:60646411		G>D	A:176	(50.46, 21.64, 42.13)
15:60646409	rs141297352	R>G	A:177	(50.61, 23.83, 38.25)
15:60646404		R>S	A:178	(44.10, 23.24, 43.01)
15:60646396		D>G	A:181	(42.49, 29.87, 48.88)
15:60646381	rs567168734	D>G	A:186	(33.97, 34.14, 40.85)
15:60646382	rs372642918	D>N	A:186	(33.97, 34.14, 40.85)
15:60646354		R>Q	A:195	(25.11, 25.67, 33.09)
15:60646355		R>W	A:195	(25.11, 25.67, 33.09)
15:60644663		A>T	A:200	(29.85, 17.04, 30.89)
15:60644650		R>T	A:204	(27.75, 14.63, 27.01)
15:60644619	rs548055644	S>R	A:214	(39.77, 21.30, 34.32)
15:60644620	rs566273872	S>N	A:214	(39.77, 21.30, 34.32)
15:60644611		T>N	A:217	(42.39, 20.26, 38.96)
15:60644608		E>G	A:218	(42.45, 24.17, 37.06)
15:60644605		R>Q	A:219	(38.75, 26.01, 39.09)
15:60644606		R>W	A:219	(38.75, 26.01, 39.09)
15:60644602		S>T	A:220	(39.79, 26.71, 44.66)
15:60644600	rs374077954 COSM1373839	V>M	A:221	(38.95, 23.95, 47.72)
15:60644015		F>S	A:228	(30.89, 20.58, 44.09)
15:60644012	rs145435452	D>G	A:229	(25.72, 24.06, 46.52)
15:60644010	rs376822302	R>G	A:230	(24.26, 26.79, 41.42)
15:60643998	rs192656325	Y>H	A:234	(21.98, 24.05, 37.26)
15:60643981		M>I	A:239	(29.39, 15.64, 41.81)
15:60643983	rs371940535	M>V	A:239	(29.39, 15.64, 41.81)
15:60643977		E>K	A:241	(25.27, 9.58, 42.51)
15:60643967		R>K	A:244	(28.63, 7.08, 42.61)
15:60643968		R>G	A:244	(28.63, 7.08, 42.61)
15:60643952		G>E	A:249	(36.93, 2.51, 38.05)
15:60643938		A>T	A:254	(39.52, 9.35, 41.65)
15:60643926		L>M	A:258	(39.03, 14.81, 44.36)
15:60643445		C>G	A:261	(39.25, 15.70, 49.69)
15:60643431	rs373839349 COSM1197332	K>N	A:265	(40.66, 16.43, 53.59)
15:60643427		L>V	A:267	(34.74, 12.55, 56.53)
15:60643411	COSM1129162	R>Q	A:272	(40.67, 5.45, 53.19)
15:60643412	rs564741326	R>W	A:272	(40.67, 5.45, 53.19)
15:60641396		G>S	A:279	(36.81, -6.15, 58.71)
15:60641386		T>M	A:282	(43.79, -4.94, 59.05)
15:60641378	rs201356127	K>E	A:285	(50.05, -0.95, 53.64)
15:60641356	rs17852168	V>A	A:292	(52.07, 8.60, 59.93)
15:60641357	COSM4055956	V>F	A:292	(52.07, 8.60, 59.93)
15:60641351		R>C	A:294	(46.69, 13.76, 57.94)
15:60641341		V>A	A:297	(47.66, 17.65, 59.77)
15:60641342		V>L	A:297	(47.66, 17.65, 59.77)
15:60641327	rs540582218	I>V	A:302	(40.15, 12.61, 61.47)
15:60641315	rs149022213	F>L	A:306	(35.60, 7.58, 63.32)
15:60641304	rs368177112	K>N	A:309	(29.95, 8.34, 60.36)
15:60641300	rs61731031	G>S	A:311	(30.02, 6.16, 67.82)
15:60641291	rs201149115	L>V	A:314	(40.06, 6.21, 65.75)
15:60641277	rs145075587	I>M	A:318	(43.07, 1.39, 66.62)
15:60641278		I>T	A:318	(43.07, 1.39, 66.62)
15:60639875		G>D	A:324	(50.78, -4.23, 70.85)
15:60639876		G>C	A:324	(50.78, -4.23, 70.85)
15:60639873		D>N	A:325	(54.35, -2.55, 70.80)
15:60639860	rs200561310	A>V	A:329	(51.74, 3.43, 68.29)
15:60639843		G>R	A:335	(46.10, 11.13, 71.10)
15:60639836		D>G	A:337	(39.53, 8.17, 73.61)