General Structure Information
| PDB ID | 1p49 |
| HGNC Gene Label(s) | STS |
| Structure Name | structure of human placental estrone/dhea sulfatase |
| Resolution | 2.6Å |
| Reference | AUTH F.G.HERNANDEZ-GUZMAN,T.HIGASHIYAMA,W.PANGBORN,Y.OSAWA,AUTH 2 D.GHOSHTITL STRUCTURE OF HUMAN ESTRONE SULFATASE SUGGESTS FUNCTIONALTITL 2 ROLES OF MEMBRANE ASSOCIATIONREF J.BIOL.CHEM. V. 278 22989 2003REFN ISSN 0021-9258PMID 12657638DOI 10.1074/JBC.M211497200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 548 |
| Number Of SNVs | 98 |
| Number Of Permutations | 66796 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.042 |
| p-value | 0.945 |
ClinVar
| Number Of Residues | 548 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1368 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 1.0 |
| p-value | 0.004 |
COSMIC
| Number Of Residues | 548 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2370 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.2 |
| p-value | 0.906 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 98 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.838 |
| p-value | 0.004 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 98 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 43.0 |
| K Statistic | -0.217 |
| p-value | 0.682 |