General Structure Information
| PDB ID | 1hdr |
| HGNC Gene Label(s) | QDPR |
| Structure Name | the crystallographic structure of a human dihydropteridine reductase nadh binary complex expressed in escherichia coli by a cdna constructed from its rat homologue |
| Resolution | 2.5Å |
| Reference | AUTH Y.SU,K.I.VARUGHESE,N.H.XUONG,T.L.BRAY,D.J.ROCHE,J.M.WHITELEYTITL THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINETITL 2 REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLITITL 3 BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE.REF J.BIOL.CHEM. V. 268 26836 1993REFN ISSN 0021-9258PMID 8262916 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 236 |
| Number Of SNVs | 68 |
| Number Of Permutations | 7018 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.025 |
| p-value | 0.052 |
ClinVar
| Number Of Residues | 236 |
| Number Of SNVs | 4 |
| Number Of Permutations | 275 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.167 |
| p-value | 0.754 |
COSMIC
| Number Of Residues | 236 |
| Number Of SNVs | 3 |
| Number Of Permutations | 160 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.667 |
| p-value | 0.753 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 68 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.095 |
| p-value | 0.622 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 68 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.289 |
| p-value | 0.993 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
