General Structure Information
| PDB ID | 3g0f |
| HGNC Gene Label(s) | KIT |
| Structure Name | kit kinase domain mutant d816h in complex with sunitinib |
| Resolution | 2.6Å |
| Reference | AUTH K.S.GAJIWALA,J.C.WU,J.CHRISTENSEN,G.D.DESHMUKH,AUTH 2 W.DIEHL,J.P.DINITTO,J.M.ENGLISH,M.J.GREIG,Y.A.HE,AUTH 3 S.L.JACQUES,E.A.LUNNEY,M.MCTIGUE,D.MOLINA,AUTH 4 T.QUENZER,P.A.WELLS,X.YU,Y.ZHANG,A.ZOU,M.R.EMMETT,AUTH 5 A.G.MARSHALL,H.M.ZHANG,G.D.DEMETRITITL KIT KINASE MUTANTS SHOW UNIQUE MECHANISMS OF DRUGTITL 2 RESISTANCE TO IMATINIB AND SUNITINIB INTITL 3 GASTROINTESTINAL STROMAL TUMOR PATIENTS.REF PROC.NATL.ACAD.SCI.USA V. 106 1542 2009REFN ISSN 0027-8424PMID 19164557DOI 10.1073/PNAS.0812413106 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 293 |
| Number Of SNVs | 37 |
| Number Of Permutations | 6439 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.014 |
| p-value | 0.168 |
ClinVar
| Number Of Residues | 293 |
| Number Of SNVs | 10 |
| Number Of Permutations | 1597 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.2 |
| p-value | 0.36 |
COSMIC
| Number Of Residues | 293 |
| Number Of SNVs | 38 |
| Number Of Permutations | 35898 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.08 |
| p-value | 0.212 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of ClinVar SNVs | 10 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.11 |
| p-value | 0.164 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 25 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.033 |
| p-value | 0.04 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
