4DYL.A | FES – ASTRID

4DYL.A | FES

General Structure Information

PDB ID	4dyl
HGNC Gene Label(s)	FES
Structure Name	f-bar domain of human fes tyrosine kinase
Resolution	2.18Å
Reference	AUTH E.UGOCHUKWU,E.SALAH,J.ELKINS,A.BARR,T.KROJER,AUTH 2 FILIPPAKOPOULOS P.,J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 C.BOUNTRA,F.VON DELFT,S.KNAPP,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL F-BAR DOMAIN OF HUMAN FES TYROSINE KINASEREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	375
Number Of SNVs	98
Number Of Permutations	84926
Optimal Distance Threshold	12.0
K Statistic	0.048
p-value	0.426

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:91428289	rs370302986	S>F	A:5	(19.87, 2.25, 42.73)
15:91428301		S>N	A:9	(20.17, -7.00, 45.53)
15:91428315	rs117804206	G>R	A:14	(16.87, -12.12, 39.94)
15:91428318		V>L	A:15	(14.70, -9.32, 38.86)
15:91428327	rs28510611	Q>K	A:18	(13.42, -13.73, 35.94)
15:91428336		E>K	A:21	(15.72, -15.47, 30.33)
15:91428348	rs376111396	R>C	A:25	(10.95, -15.76, 27.00)
15:91428349		R>H	A:25	(10.95, -15.76, 27.00)
15:91428360	rs139960065	G>R	A:29	(8.97, -14.16, 18.63)
15:91428361		G>V	A:29	(8.97, -14.16, 18.63)
15:91428363		M>V	A:30	(10.23, -10.28, 17.14)
15:91428376		M>R	A:34	(10.10, -10.88, 11.43)
15:91428384		R>G	A:37	(5.29, -10.24, 6.43)
15:91428391		K>R	A:39	(6.22, -18.36, 4.41)
15:91428411	rs368643135 COSM966573 COSM966572	G>R	A:46	(3.45, -16.44, -6.35)
15:91428423		H>D	A:50	(-0.51, -18.61, -11.24)
15:91428477	rs140249304	P>S	A:68	(-7.67, 0.96, -26.08)
15:91428645		W>G	A:73	(-5.78, -6.93, -19.08)
15:91428672		G>S	A:82	(5.71, -6.13, -10.34)
15:91428681	rs56041861	R>C	A:85	(8.87, -8.50, -10.13)
15:91428682		R>H	A:85	(8.87, -8.50, -10.13)
15:91428686		L>F	A:86	(8.21, -5.39, -4.79)
15:91428690		R>W	A:88	(10.26, -12.03, -5.38)
15:91428691	COSM4057926 COSM4057925	R>Q	A:88	(10.26, -12.03, -5.38)
15:91428699		A>T	A:91	(11.39, -11.29, 1.54)
15:91428714		S>T	A:96	(19.07, -9.96, 4.76)
15:91428728		S>R	A:100	(19.84, -11.07, 10.60)
15:91428732		L>V	A:102	(16.56, -10.31, 15.75)
15:91428747	rs544318873	R>W	A:107	(23.40, -14.39, 20.51)
15:91428748		R>Q	A:107	(23.40, -14.39, 20.51)
15:91428753		R>W	A:109	(20.09, -10.19, 24.89)
15:91428754	rs145079846	R>Q	A:109	(20.09, -10.19, 24.89)
15:91428760	rs535474019	Q>R	A:111	(26.48, -14.38, 26.20)
15:91428765		R>C	A:113	(23.24, -13.99, 30.46)
15:91428778		S>N	A:117	(26.08, -14.39, 36.04)
15:91428794		Q>H	A:122	(33.56, -13.48, 39.74)
15:91428806		E>D	A:126	(35.69, -11.80, 46.46)
15:91430207		I>T	A:135	(37.93, -11.92, 59.21)
15:91430240	rs201938748	A>V	A:146	(45.39, -15.86, 73.86)
15:91430242		R>W	A:147	(45.03, -19.03, 75.36)
15:91430245		D>N	A:148	(49.27, -20.01, 74.35)
15:91430257		A>T	A:152	(52.24, -18.99, 79.77)
15:91430258		A>D	A:152	(52.24, -18.99, 79.77)
15:91430263	COSM1206996	R>C	A:154	(48.47, -20.52, 85.53)
15:91430264	rs372642630 COSM966577 COSM966576	R>H	A:154	(48.47, -20.52, 85.53)
15:91430433	COSM4151203 COSM4151202	K>N	A:167	(61.87, -21.09, 80.73)
15:91430438		K>R	A:169	(59.72, -16.37, 80.61)
15:91430452	rs201771040 COSM1375475 COSM1375474	R>C	A:174	(59.35, -17.37, 72.77)
15:91430465		K>R	A:178	(53.26, -14.81, 68.44)
15:91430467		L>I	A:179	(49.24, -12.22, 70.76)
15:91430474	rs373485327	A>G	A:181	(51.66, -9.99, 65.53)
15:91430479		H>Y	A:183	(46.41, -7.11, 67.38)
15:91430485	rs138511924	R>C	A:185	(47.22, -8.82, 61.21)
15:91430497		G>S	A:189	(42.18, -7.09, 57.86)
15:91430504		R>Q	A:191	(40.38, -0.32, 57.24)
15:91430510		A>V	A:193	(37.44, -5.70, 54.82)
15:91430525	rs145301509	Q>R	A:198	(33.64, 1.23, 51.02)
15:91430536		Q>E	A:202	(29.97, 2.66, 47.55)
15:91430551	COSM4057930 COSM4057929	G>S	A:207	(28.82, -0.88, 37.97)
15:91430552	rs377603197	G>D	A:207	(28.82, -0.88, 37.97)
15:91430560		R>W	A:210	(25.30, 1.38, 34.95)
15:91430578		H>Y	A:216	(19.82, -4.38, 28.46)
15:91430593		C>S	A:221	(18.21, 1.30, 20.07)
15:91432544		I>T	A:226	(15.31, -4.35, 14.17)
15:91432569		S>R	A:234	(6.98, -4.58, 4.96)
15:91432576	rs138932852	V>M	A:237	(2.08, 2.01, 1.70)
15:91432582		D>H	A:239	(7.20, 5.44, -2.68)
15:91432591		V>M	A:242	(2.20, 4.10, -4.80)
15:91432595	rs143351963	A>V	A:243	(3.89, 3.60, -8.46)
15:91432603	rs141047785	R>W	A:246	(0.19, 6.69, -8.58)
15:91432604	rs34573430	R>Q	A:246	(0.19, 6.69, -8.58)
15:91432607		E>V	A:247	(1.09, 3.44, -13.97)
15:91432611		M>I	A:248	(-2.54, -0.24, -12.12)
15:91432627	rs149847085	R>C	A:254	(-4.88, 5.57, -20.29)
15:91432628	rs145351114	R>H	A:254	(-4.88, 5.57, -20.29)
15:91432655		G>V	A:263	(-8.62, 0.46, -35.30)
15:91432660		L>V	A:265	(-13.17, 0.08, -38.11)
15:91432664		R>Q	A:266	(-8.42, 3.21, -38.25)
15:91432668		Q>H	A:267	(-6.91, -3.83, -39.44)
15:91432751	COSM3817066 COSM3817065	A>T	A:271	(-16.79, -0.87, -48.74)
15:91432755		P>L	A:272	(-20.22, -1.00, -48.66)
15:91432757		D>N	A:273	(-21.39, -5.76, -50.64)
15:91432776		T>M	A:279	(-33.97, -4.33, -63.38)
15:91432814		E>K	A:292	(-42.45, 0.31, -71.49)
15:91432816		E>D	A:292	(-42.45, 0.31, -71.49)
15:91432818	rs188344412	P>H	A:293	(-39.32, -0.13, -69.88)
15:91432821		G>E	A:294	(-41.72, -1.42, -66.55)
15:91432856	rs373788500	V>M	A:306	(-55.28, -2.38, -62.06)
15:91432866	rs368178849	T>M	A:309	(-54.24, -4.57, -57.40)
15:91433093		L>P	A:317	(-50.21, 0.38, -47.04)
15:91433098		V>M	A:319	(-52.00, -3.52, -42.23)
15:91433104	rs201729285	T>S	A:321	(-49.07, 1.84, -41.57)
15:91433105		T>I	A:321	(-49.07, 1.84, -41.57)
15:91433122	rs199975821	R>W	A:327	(-43.28, -2.50, -34.42)
15:91433123	rs144946287	R>Q	A:327	(-43.28, -2.50, -34.42)
15:91433138	rs149066819	T>M	A:332	(-41.34, 4.75, -27.31)
15:91433146		Q>K	A:335	(-36.55, 4.38, -25.98)
15:91433159	COSM966586 COSM966585	R>Q	A:339	(-34.06, 6.38, -19.44)
15:91433167	rs376898394	E>K	A:342	(-29.95, 4.58, -17.93)
15:91433170	COSM3887791 COSM3887790	E>Q	A:343	(-31.45, 7.56, -13.87)
15:91433171	rs139208515	E>G	A:343	(-31.45, 7.56, -13.87)
15:91433175		N>K	A:344	(-32.72, 4.99, -11.08)
15:91433177		T>I	A:345	(-28.59, 2.62, -12.44)
15:91433185	rs371311890	R>W	A:348	(-18.65, 0.92, -10.52)
15:91433186		R>Q	A:348	(-18.65, 0.92, -10.52)
15:91433191	COSM4057939 COSM4057938	R>W	A:350	(-24.63, 1.02, -17.20)
15:91433386		C>S	A:372	(-39.43, -2.32, -45.69)
15:91433407		A>T	A:379	(-44.32, 1.71, -54.43)
15:91433438		E>G	A:389	(-54.70, 8.87, -63.22)
15:91433447		G>V	A:392	(-59.10, 8.62, -66.41)
15:91433452		G>S	A:394	(-60.73, 7.13, -70.30)
15:91433455	COSM3794519 COSM3794518	E>K	A:395	(-61.11, 4.67, -72.63)
15:91433461		P>S	A:397	(-56.82, 1.08, -74.09)
15:91433464		P>S	A:398	(-58.30, -0.90, -77.41)