General Structure Information
| PDB ID | 2i5f |
| HGNC Gene Label(s) | PLEK |
| Structure Name | crystal structure of the c-terminal ph domain of pleckstrin in complex with d-myo-ins(1,2,3,5,6)p5 |
| Resolution | 1.35Å |
| Reference | AUTH S.G.JACKSON,Y.ZHANG,R.J.HASLAM,M.S.JUNOPTITL STRUCTURAL ANALYSIS OF THE CARBOXY TERMINAL PHTITL 2 DOMAIN OF PLECKSTRIN BOUND TO D-MYO-INOSITOLTITL 3 1,2,3,5,6-PENTAKISPHOSPHATE.REF BMC STRUCT.BIOL. V. 7 80 2007REFN ESSN 1472-6807PMID 18034889DOI 10.1186/1472-6807-7-80 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 96 |
| Number Of SNVs | 29 |
| Number Of Permutations | 5061 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.155 |
| p-value | 0.112 |
COSMIC
| Number Of Residues | 96 |
| Number Of SNVs | 3 |
| Number Of Permutations | 165 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.667 |
| p-value | 0.863 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.281 |
| p-value | 0.705 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
