3B97.B | ENO1 – ASTRID

3B97.B | ENO1

General Structure Information

PDB ID	3b97
HGNC Gene Label(s)	ENO1
Structure Name	crystal structure of human enolase 1
Resolution	2.2Å
Reference	AUTH H.J.KANG,S.K.JUNG,S.J.KIM,S.J.CHUNGTITL STRUCTURE OF HUMAN ALPHA-ENOLASE (HENO1), ATITL 2 MULTIFUNCTIONAL GLYCOLYTIC ENZYME.REF ACTA CRYSTALLOGR.,SECT.D V. 64 651 2008REFN ISSN 0907-4449PMID 18560153DOI 10.1107/S0907444908008561

Variant Set Distributions

ExAC Variants

Number Of Residues	432
Number Of SNVs	115
Number Of Permutations	18723
Optimal Distance Threshold	9.0
K Statistic	0.031
p-value	0.313

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:8934961	COSM1296763	I>V	B:2	(84.47, -34.81, 37.49)
1:8934950		I>M	B:5	(84.86, -28.46, 34.50)
1:8934948		H>R	B:6	(87.30, -24.58, 30.58)
1:8934943		R>G	B:8	(85.23, -22.63, 25.72)
1:8934933		F>S	B:11	(80.32, -17.31, 18.31)
1:8934924	rs11544495	R>H	B:14	(70.73, -16.56, 15.63)
1:8934925		R>C	B:14	(70.73, -16.56, 15.63)
1:8934922		G>R	B:15	(76.31, -15.13, 16.04)
1:8934898	rs376026081	L>I	B:23	(83.91, -32.80, 31.40)
1:8932043		L>F	B:29	(87.26, -34.07, 26.14)
1:8932006	rs372656945	G>A	B:41	(59.15, -17.80, 27.08)
1:8932000	rs138834005	Y>C	B:43	(56.21, -18.62, 32.26)
1:8931988		E>G	B:47	(69.34, -17.00, 28.12)
1:8931982	rs573584202	R>Q	B:49	(72.71, -13.38, 27.13)
1:8931983		R>W	B:49	(72.71, -13.38, 27.13)
1:8931968		T>S	B:54	(79.70, -2.40, 24.29)
1:8931964	rs201990176	R>H	B:55	(81.13, -8.19, 24.58)
1:8931965		R>C	B:55	(81.13, -8.19, 24.58)
1:8931956	rs142310173	G>R	B:58	(74.51, -7.82, 25.09)
1:8930542	rs201867667	N>S	B:69	(85.13, -21.50, 35.10)
1:8930528	rs146938354	P>T	B:74	(85.11, -25.88, 41.70)
1:8930519	rs146619828	V>F	B:77	(86.20, -31.24, 41.11)
1:8930513		K>E	B:79	(81.51, -32.81, 45.94)
1:8928110		N>D	B:82	(80.25, -40.90, 38.80)
1:8928075	rs11544491	M>I	B:93	(74.02, -27.86, 39.47)
1:8928076		M>T	B:93	(74.02, -27.86, 39.47)
1:8928072	COSM1344695	I>M	B:94	(69.27, -27.26, 41.12)
1:8928071		E>K	B:95	(70.85, -27.87, 45.84)
1:8928052		N>S	B:101	(63.80, -19.57, 37.05)
1:8927304		F>V	B:105	(74.72, -20.33, 38.78)
1:8927298		A>T	B:107	(70.36, -22.14, 32.43)
1:8927291		A>V	B:109	(75.47, -22.77, 32.95)
1:8927292		A>T	B:109	(75.47, -22.77, 32.95)
1:8927280		V>M	B:113	(77.76, -28.95, 33.10)
1:8927268	rs199529530	V>I	B:117	(77.92, -35.02, 32.84)
1:8927250	rs11544519	V>I	B:123	(82.15, -43.09, 27.70)
1:8927238		V>I	B:127	(77.11, -47.04, 26.35)
1:8927235		P>S	B:128	(75.85, -45.90, 23.40)
1:8927225	rs529227052	R>H	B:131	(70.98, -47.81, 25.51)
1:8927226		R>C	B:131	(70.98, -47.81, 25.51)
1:8927222		H>R	B:132	(73.47, -42.97, 29.87)
1:8927223		H>Y	B:132	(73.47, -42.97, 29.87)
1:8927217		A>S	B:134	(67.67, -44.98, 28.25)
1:8927198		S>C	B:140	(64.53, -50.98, 27.08)
1:8927192		V>G	B:142	(65.81, -47.44, 21.29)
1:8926553	rs527568599	N>S	B:150	(60.99, -25.47, 9.59)
1:8926547		I>S	B:152	(58.29, -22.37, 5.14)
1:8926544		N>S	B:153	(61.03, -20.09, 8.15)
1:8926529		A>V	B:158	(61.95, -14.41, 9.35)
1:8926523		N>S	B:160	(58.63, -12.67, 6.53)
1:8926521	rs566372119	K>Q	B:161	(54.33, -9.52, 5.94)
1:8926511		M>T	B:164	(52.07, -18.49, 11.55)
1:8926509		Q>K	B:165	(57.76, -19.70, 14.16)
1:8926485	rs371371408	G>S	B:173	(56.00, -43.14, 5.45)
1:8926482		A>T	B:174	(59.02, -43.86, 5.88)
1:8926474	rs11544513	N>K	B:176	(63.97, -45.90, 6.91)
1:8926475	rs371286872	N>S	B:176	(63.97, -45.90, 6.91)
1:8926471	COSM81131	F>L	B:177	(65.91, -41.16, 9.92)
1:8926460	rs543941599	M>T	B:181	(66.55, -37.42, 5.79)
1:8926461		M>V	B:181	(66.55, -37.42, 5.79)
1:8926457	COSM912894	R>H	B:182	(65.06, -40.02, -0.74)
1:8926458		R>C	B:182	(65.06, -40.02, -0.74)
1:8926455		I>V	B:183	(61.31, -37.95, 1.77)
1:8926436	rs201627070	H>R	B:189	(65.91, -29.64, -2.64)
1:8926432	rs368175966	N>K	B:190	(60.77, -29.98, -5.30)
1:8926433	COSM3386382	N>S	B:190	(60.77, -29.98, -5.30)
1:8926419	rs199771237	I>V	B:195	(59.01, -20.68, -3.77)
1:8926395		A>T	B:203	(61.89, -16.15, -2.11)
1:8926388		N>S	B:205	(66.78, -16.41, 0.49)
1:8926378		D>E	B:208	(67.06, -18.34, 11.80)
1:8926371	rs201238976 COSM122839	G>R	B:211	(63.96, -22.08, 5.70)
1:8926364		A>V	B:213	(61.84, -16.66, 3.28)
1:8926356		I>F	B:216	(54.29, -14.77, 2.14)
1:8926341		E>K	B:221	(50.51, -19.57, 0.10)
1:8925523		T>I	B:228	(52.69, -28.02, -4.30)
1:8925503		Y>H	B:235	(57.49, -38.50, -1.63)
1:8925492		K>N	B:238	(55.36, -41.49, 2.14)
1:8925494		K>E	B:238	(55.36, -41.49, 2.14)
1:8925485	rs138820314	I>V	B:241	(51.71, -30.58, 7.39)
1:8925482	rs143707545	G>S	B:242	(53.26, -29.00, 10.66)
1:8925478		M>T	B:243	(51.80, -25.63, 12.07)
1:8925479		M>V	B:243	(51.80, -25.63, 12.07)
1:8925461	rs11544512	E>Q	B:249	(56.02, -13.94, 19.61)
1:8925454		F>C	B:251	(48.78, -12.03, 23.42)
1:8925424		K>R	B:261	(56.47, -9.10, 11.17)
1:8925409		P>R	B:266	(44.62, -2.60, 16.78)
1:8925394	rs377334028	S>L	B:271	(39.64, -13.72, 18.40)
1:8925356		K>E	B:284	(38.68, -28.76, 6.54)
1:8925349		Y>S	B:286	(45.76, -27.43, 3.70)
1:8924143	rs533860041	I>V	B:291	(49.05, -27.13, 15.77)
1:8924137	rs368960957	D>H	B:293	(52.32, -22.56, 20.85)
1:8924113		G>R	B:301	(41.15, -21.72, 27.51)
1:8924109		A>G	B:302	(41.90, -21.64, 24.33)
1:8924088	rs374667746	S>N	B:309	(37.87, -29.37, 19.07)
1:8924089		S>G	B:309	(37.87, -29.37, 19.07)
1:8924085		A>V	B:310	(40.85, -30.35, 16.73)
1:8924080		I>F	B:312	(45.09, -32.36, 16.01)
1:8924032		A>T	B:328	(50.70, -30.56, 35.62)
1:8924025	rs267598750	A>D	B:330	(48.19, -29.23, 31.33)
1:8924026		A>S	B:330	(48.19, -29.23, 31.33)
1:8924023		V>M	B:331	(47.83, -32.72, 32.48)
1:8924017	rs371689591	E>K	B:333	(43.33, -27.64, 32.65)
1:8924014		K>E	B:334	(42.45, -32.32, 29.22)
1:8923981		Q>E	B:345	(62.40, -24.38, 27.94)
1:8923969		V>M	B:349	(69.27, -33.82, 31.61)
1:8923966		T>A	B:350	(67.18, -34.64, 35.34)
1:8923963		E>K	B:351	(64.66, -30.75, 35.36)
1:8923954		Q>K	B:354	(61.79, -35.06, 35.66)
1:8923950		A>V	B:355	(59.11, -33.85, 31.67)
1:8923382	rs151047591	N>S	B:362	(49.70, -38.39, 31.53)
1:8923374		G>S	B:365	(53.42, -36.64, 23.54)
1:8923370		V>A	B:366	(57.21, -36.11, 23.38)
1:8923371		V>I	B:366	(57.21, -36.11, 23.38)
1:8923355	rs569618357	R>H	B:371	(65.57, -23.23, 21.13)
1:8923356	rs150781341	R>C	B:371	(65.57, -23.23, 21.13)
1:8923352	rs143592223	S>L	B:372	(66.46, -20.89, 16.73)
1:8923350		G>R	B:373	(69.68, -21.34, 18.31)
1:8923343		T>I	B:375	(75.24, -25.48, 18.18)
1:8923341		E>K	B:376	(78.56, -27.28, 16.66)
1:8923334		T>I	B:378	(74.57, -33.79, 18.34)
1:8923332		F>L	B:379	(72.27, -34.44, 23.98)
1:8923329		I>V	B:380	(68.80, -33.31, 20.42)
1:8923317		V>L	B:384	(64.89, -38.62, 20.58)
1:8923004		I>V	B:392	(62.88, -34.62, 16.23)
1:8922973	rs201032262	R>H	B:402	(69.53, -26.81, 12.34)
1:8921486	rs201317089	I>T	B:412	(71.96, -43.71, 15.84)
1:8921477		E>G	B:415	(75.29, -48.02, 16.09)
1:8921471		G>D	B:417	(70.65, -51.96, 12.43)
1:8921462	rs373459987	A>G	B:420	(66.25, -50.78, 13.75)
1:8921454	rs369746357	A>P	B:423	(58.03, -44.51, 14.28)
1:8921451	COSM1582258	G>S	B:424	(56.48, -43.31, 11.81)
1:8921432		P>R	B:430	(56.25, -45.06, 19.52)