General Structure Information
| PDB ID | 2ouj |
| HGNC Gene Label(s) | THBS1 |
| Structure Name | the crystal structure of the thrombospondin-1 n-terminal domain in complex with fractionated heparin dp8 |
| Resolution | 1.9Å |
| Reference | AUTH K.TAN,M.DUQUETTE,J.H.LIU,K.SHANMUGASUNDARAM,AUTH 2 A.JOACHIMIAK,J.T.GALLAGHER,A.C.RIGBY,J.H.WANG,AUTH 3 J.LAWLERTITL HEPARIN-INDUCED CIS- AND TRANS-DIMERIZATION MODESTITL 2 OF THE THROMBOSPONDIN-1 N-TERMINAL DOMAIN.REF J.BIOL.CHEM. V. 283 3932 2008REFN ISSN 0021-9258PMID 18065761DOI 10.1074/JBC.M705203200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 204 |
| Number Of SNVs | 45 |
| Number Of Permutations | 3565 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.162 |
| p-value | 0.586 |
COSMIC
| Number Of Residues | 204 |
| Number Of SNVs | 3 |
| Number Of Permutations | 104 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 0.667 |
| p-value | 0.716 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 45 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.469 |
| p-value | 0.266 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
