General Structure Information
| PDB ID | 1fq3 |
| HGNC Gene Label(s) | GZMB |
| Structure Name | crystal structure of human granzyme b |
| Resolution | 3.1Å |
| Reference | AUTH E.ESTEBANEZ-PERPINA,P.FUENTES-PRIOR,D.BELORGEY,M.BRAUN,AUTH 2 R.KIEFERSAUER,K.MASKOS,R.HUBER,H.RUBIN,W.BODETITL CRYSTAL STRUCTURE OF THE CASPASE ACTIVATOR HUMAN GRANZYME B,TITL 2 A PROTEINASE HIGHLY SPECIFIC FOR AN ASP-P1 RESIDUE.REF BIOL.CHEM. V. 381 1203 2000REFN ISSN 1431-6730PMID 11209755DOI 10.1515/BC.2000.148 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 221 |
| Number Of SNVs | 57 |
| Number Of Permutations | 5841 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.127 |
| p-value | 0.541 |
COSMIC
| Number Of Residues | 221 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2236 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.267 |
| p-value | 0.604 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.103 |
| p-value | 0.546 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
