3O8Y.B | ALOX5

General Structure Information

PDB ID	3o8y
HGNC Gene Label(s)	ALOX5
Structure Name	stable-5-lipoxygenase
Resolution	2.39Å
Reference	AUTH N.C.GILBERT,S.G.BARTLETT,M.T.WAIGHT,D.B.NEAU,W.E.BOEGLIN,AUTH 2 A.R.BRASH,M.E.NEWCOMERTITL THE STRUCTURE OF HUMAN 5-LIPOXYGENASE.REF SCIENCE V. 331 217 2011REFN ISSN 0036-8075PMID 21233389DOI 10.1126/SCIENCE.1197203

Variant Set Distributions

ExAC Variants

Number Of Residues	670
Number Of SNVs	178
Number Of Permutations	78465
Optimal Distance Threshold	21.0
K Statistic	0.169
p-value	0.01

COSMIC

Number Of Residues	670
Number Of SNVs	18
Number Of Permutations	11164
Optimal Distance Threshold	13.0
K Statistic	0.033
p-value	0.767

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	178
Number Of COSMIC SNVs	17
Optimal Distance Threshold	8.0
K Statistic	-0.014
p-value	0.625

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:45869731		P>S	B:4	(-14.02, 93.08, 51.19)
10:45869753		A>V	B:11	(-12.63, 86.88, 28.03)
10:45869791		I>V	B:24	(-21.92, 81.87, 33.43)
10:45869803		L>F	B:28	(-12.94, 82.04, 43.52)
10:45869807		V>E	B:29	(-10.94, 76.36, 44.61)
10:45869813		S>L	B:31	(-5.32, 77.21, 50.06)
10:45869821		C>R	B:34	(-14.09, 77.01, 48.24)
10:45869822		C>Y	B:34	(-14.09, 77.01, 48.24)
10:45869825	rs532658793	S>T	B:35	(-16.05, 80.48, 47.16)
10:45869876		A>V	B:49	(-17.25, 90.41, 25.15)
10:45877936		D>E	B:51	(-17.63, 90.81, 31.03)
10:45877943		D>N	B:54	(-17.10, 93.65, 41.80)
10:45877946	rs139425864	V>M	B:55	(-16.87, 88.53, 43.22)
10:45877956		D>G	B:58	(-18.27, 84.51, 52.77)
10:45877958		E>K	B:59	(-14.74, 82.67, 53.74)
10:45877967		G>C	B:62	(-6.33, 82.50, 50.48)
10:45877970	rs143978950	E>K	B:63	(-2.80, 81.17, 47.00)
10:45877998		R>H	B:72	(-26.80, 76.23, 36.72)
10:45878013		N>S	B:77	(-27.97, 74.70, 24.98)
10:45878014		N>K	B:77	(-27.97, 74.70, 24.98)
10:45878016		D>A	B:78	(-26.12, 79.13, 23.89)
10:45878019		D>G	B:79	(-22.36, 76.54, 22.97)
10:45878036		I>V	B:85	(-11.50, 83.59, 34.11)
10:45878040		T>M	B:86	(-8.17, 87.61, 34.76)
10:45878049	rs551364951 COSM1505458	T>M	B:89	(-6.64, 88.75, 44.57)
10:45878051		P>T	B:90	(-8.61, 90.47, 48.09)
10:45878067		I>N	B:95	(-4.16, 85.10, 39.75)
10:45878069		E>K	B:96	(-4.09, 84.99, 33.50)
10:45878082		Y>C	B:100	(-7.89, 80.15, 25.36)
10:45878096	COSM3978521	G>S	B:105	(-23.62, 72.71, 30.04)
10:45878100	rs373380498	D>A	B:106	(-22.51, 68.91, 29.31)
10:45878105	COSM342079	E>K	B:108	(-17.82, 72.13, 36.68)
10:45878121	COSM1627503	D>A	B:113	(-2.80, 79.63, 37.37)
10:45878126	COSM918268	R>C	B:115	(2.15, 79.85, 37.91)
10:45878127		R>H	B:115	(2.15, 79.85, 37.91)
10:45891307		K>N	B:117	(3.26, 74.49, 37.72)
10:45891332		I>V	B:126	(-6.59, 71.79, 46.34)
10:45891344		H>Y	B:130	(-7.64, 69.90, 38.54)
10:45891346	rs372437573	H>Q	B:130	(-7.64, 69.90, 38.54)
10:45891348	COSM918269	R>Q	B:131	(-1.67, 67.74, 36.86)
10:45891350	rs187523060	R>C	B:132	(-6.25, 61.02, 40.02)
10:45891351	rs148401371	R>H	B:132	(-6.25, 61.02, 40.02)
10:45891359	COSM918270	L>M	B:135	(-4.80, 63.42, 32.83)
10:45891368	rs199726828	R>W	B:138	(-7.78, 65.91, 28.60)
10:45891375		K>R	B:140	(-14.30, 58.96, 30.52)
10:45891384		R>Q	B:143	(-11.69, 56.23, 24.63)
10:45907676	rs560031203 COSM278791	D>H	B:156	(-13.37, 57.21, 18.98)
10:45907690		H>Q	B:160	(-17.29, 67.50, 12.83)
10:45907694		D>Y	B:162	(-19.64, 62.63, 17.07)
10:45907704		R>H	B:165	(-17.91, 72.59, 20.17)
10:45907719		D>V	B:170	(-15.18, 77.59, 15.04)
10:45907752		Y>S	B:181	(-14.11, 69.81, -2.82)
10:45907761		A>V	B:184	(-14.74, 75.61, -5.57)
10:45919512		R>H	B:192	(-20.27, 74.54, -17.72)
10:45919517		M>V	B:194	(-20.87, 69.19, -11.33)
10:45919524		M>R	B:196	(-20.48, 66.55, -18.23)
10:45919535		S>T	B:200	(-13.58, 63.52, -23.69)
10:45919536		S>C	B:200	(-13.58, 63.52, -23.69)
10:45919550		A>T	B:205	(-7.58, 74.01, -27.43)
10:45919553	COSM388924	D>N	B:206	(-11.36, 72.40, -25.41)
10:45919558		F>L	B:207	(-8.47, 72.06, -19.96)
10:45919571		V>I	B:212	(-7.26, 80.76, -20.21)
10:45919574		K>E	B:213	(-12.51, 81.35, -18.38)
10:45919576		K>N	B:213	(-12.51, 81.35, -18.38)
10:45919584		N>S	B:216	(-2.58, 80.87, -10.55)
10:45919586		T>A	B:217	(1.62, 83.34, -11.42)
10:45920411		R>Q	B:221	(5.71, 80.26, -15.74)
10:45920416		M>V	B:223	(-0.74, 77.01, -19.92)
10:45920418		M>I	B:223	(-0.74, 77.01, -19.92)
10:45920420		N>S	B:224	(2.88, 78.46, -21.19)
10:45920440		M>V	B:231	(8.61, 72.86, -15.91)
10:45920441		M>R	B:231	(8.61, 72.86, -15.91)
10:45920444		F>C	B:232	(9.06, 65.86, -15.85)
10:45920447		G>V	B:233	(12.31, 67.84, -13.53)
10:45920450		Y>C	B:234	(11.61, 73.29, -11.12)
10:45920458		L>V	B:237	(14.33, 69.43, -7.01)
10:45920474		P>L	B:242	(9.07, 68.39, -3.13)
10:45920483		I>N	B:245	(14.39, 63.22, -6.49)
10:45920485	rs146711717	R>W	B:246	(16.05, 58.18, -3.21)
10:45920489	COSM216253	R>H	B:247	(23.02, 60.74, -4.48)
10:45920518	COSM918274	V>L	B:257	(19.01, 52.13, -18.68)
10:45920525	COSM230659	T>M	B:259	(25.75, 54.38, -22.16)
10:45920530		M>L	B:261	(18.83, 53.25, -24.11)
10:45920536		E>K	B:263	(24.29, 58.24, -26.22)
10:45920538		E>D	B:263	(24.29, 58.24, -26.22)
10:45920539		C>R	B:264	(21.62, 61.92, -26.73)
10:45920552		R>Q	B:268	(28.92, 65.63, -17.30)
10:45920561		S>I	B:271	(29.54, 55.98, -19.21)
10:45920566		E>K	B:273	(27.50, 52.79, -15.94)
10:45924073		N>T	B:280	(25.94, 63.29, -12.16)
10:45924084	COSM1347871	V>M	B:284	(11.45, 59.38, -8.93)
10:45924108	rs150216824	I>V	B:292	(-2.29, 50.14, -5.42)
10:45924111	COSM918275	D>N	B:293	(-6.67, 48.07, -6.56)
10:45924128		D>E	B:298	(-17.29, 54.36, -13.08)
10:45924136	rs201471525	T>I	B:301	(-14.65, 55.22, -16.82)
10:45924150		A>T	B:306	(1.37, 53.25, -13.54)
10:45924177		N>H	B:315	(22.13, 69.16, -17.14)
10:45924196		V>D	B:321	(16.92, 66.81, -17.08)
10:45924201		I>V	B:323	(18.04, 60.49, -18.74)
10:45924202		I>T	B:323	(18.04, 60.49, -18.74)
10:45935882	rs138855994	N>S	B:328	(5.14, 49.13, -15.52)
10:45935897		D>G	B:333	(9.12, 42.95, -24.68)
10:45935899		E>K	B:334	(5.02, 43.99, -23.14)
10:45935905	rs28395860	P>S	B:336	(8.24, 50.01, -23.41)
10:45935918		P>L	B:340	(14.52, 61.84, -24.28)
10:45935945		L>S	B:349	(1.64, 59.09, -22.95)
10:45935951		K>T	B:351	(7.52, 63.66, -19.99)
10:45935959		V>M	B:354	(6.15, 59.81, -14.28)
10:45935962		R>C	B:355	(3.86, 64.91, -12.99)
10:45935963		R>H	B:355	(3.86, 64.91, -12.99)
10:45935977		H>D	B:360	(-1.93, 58.91, -7.88)
10:45935980		V>I	B:361	(2.73, 58.90, -4.18)
10:45935989		T>A	B:364	(-2.62, 58.80, -0.30)
10:45936011		T>I	B:371	(1.37, 65.68, 6.80)
10:45936014		H>L	B:372	(-3.60, 65.57, 7.23)
10:45936022		S>T	B:375	(-0.46, 65.70, 12.68)
10:45936035		G>A	B:379	(-2.80, 65.41, 18.89)
10:45936041	rs143675525	A>V	B:381	(-1.36, 61.68, 22.25)
10:45936046		Y>H	B:383	(-6.22, 67.14, 23.27)
10:45936052		Q>K	B:385	(-1.65, 61.02, 27.95)
10:45936805		H>R	B:399	(1.52, 74.01, 16.50)
10:45936840		R>C	B:411	(-11.31, 60.14, 9.15)
10:45936841		R>P	B:411	(-11.31, 60.14, 9.15)
10:45936858		E>K	B:417	(-16.66, 53.20, 1.34)
10:45936864		G>S	B:419	(-16.50, 59.52, -1.21)
10:45938489		N>D	B:425	(-9.04, 60.41, -7.48)
10:45938491	rs537072496	N>K	B:425	(-9.04, 60.41, -7.48)
10:45938493		A>D	B:426	(-7.13, 56.47, -10.31)
10:45938508		G>E	B:431	(-6.52, 51.93, -3.59)
10:45938510		H>N	B:432	(-7.53, 55.47, -1.10)
10:45938513	COSM1244862	V>M	B:433	(-7.34, 52.18, 2.02)
10:45938516		Q>K	B:434	(-4.39, 48.82, -1.18)
10:45938517		Q>R	B:434	(-4.39, 48.82, -1.18)
10:45938531		A>T	B:439	(3.18, 53.60, 3.20)
10:45938532		A>V	B:439	(3.18, 53.60, 3.20)
10:45938535		M>R	B:440	(1.85, 52.63, 8.60)
10:45938552	rs28395869	A>S	B:446	(14.08, 58.90, 10.90)
10:45938555	rs375848132	S>P	B:447	(11.24, 59.72, 7.86)
10:45938567		P>S	B:451	(17.58, 67.48, 8.98)
10:45938578	rs201465951	I>M	B:454	(16.94, 66.16, 2.73)
10:45938579		K>E	B:455	(22.61, 63.63, 5.40)
10:45938582		A>T	B:456	(18.38, 59.52, 3.68)
10:45938618		Y>H	B:468	(15.98, 70.24, -3.21)
10:45938633	COSM3437922	D>N	B:473	(13.55, 76.89, 2.44)
10:45938636		G>R	B:474	(13.17, 73.54, 5.00)
10:45938639		L>F	B:475	(17.61, 72.34, 6.11)
10:45938640		L>H	B:475	(17.61, 72.34, 6.11)
10:45938651		E>K	B:479	(17.49, 74.99, 12.74)
10:45938661		R>K	B:482	(16.18, 71.10, 17.37)
10:45938867		F>L	B:484	(10.29, 77.99, 20.04)
10:45938874		E>K	B:487	(14.47, 78.49, 24.27)
10:45938875		E>V	B:487	(14.47, 78.49, 24.27)
10:45938886		I>V	B:491	(12.08, 77.99, 30.05)
10:45938898		G>S	B:495	(17.39, 68.41, 33.24)
10:45938899		G>D	B:495	(17.39, 68.41, 33.24)
10:45938905		Q>R	B:497	(16.78, 63.14, 36.49)
10:45938907		V>M	B:498	(13.38, 66.89, 35.23)
10:45938910		V>M	B:499	(13.05, 65.12, 30.32)
10:45938917	rs373344486	E>A	B:501	(11.80, 61.57, 36.42)
10:45938926		E>G	B:504	(2.11, 63.49, 32.44)
10:45938929		L>P	B:505	(7.01, 63.77, 28.34)
10:45938944		N>S	B:510	(4.17, 55.08, 25.40)
10:45938946	COSM3437923	D>N	B:511	(-0.08, 57.06, 23.68)
10:45938953		Y>S	B:513	(5.98, 52.97, 20.10)
10:45938964		M>L	B:517	(2.71, 55.04, 15.01)
10:45938965		M>R	B:517	(2.71, 55.04, 15.01)
10:45938970		G>C	B:519	(3.63, 49.58, 18.21)
10:45938971		G>D	B:519	(3.63, 49.58, 18.21)
10:45938973	COSM4014266	R>C	B:520	(5.34, 49.73, 12.93)
10:45938976		K>E	B:521	(11.27, 46.58, 16.81)
10:45938977		K>M	B:521	(11.27, 46.58, 16.81)
10:45939247	COSM252338	A>S	B:548	(6.55, 73.48, 7.67)
10:45939619	rs143439556	P>L	B:576	(2.12, 53.36, -23.38)
10:45939631		G>D	B:580	(5.19, 54.50, -32.25)
10:45939633		V>M	B:581	(1.22, 53.11, -31.47)
10:45939661	rs146768497	T>M	B:590	(-5.56, 58.76, -21.80)
10:45939675		G>S	B:595	(-16.15, 65.61, -15.07)
10:45939678		R>G	B:596	(-13.67, 61.43, -13.77)
10:45939685		C>Y	B:598	(-14.61, 69.72, -12.74)
10:45939731		N>K	B:613	(-8.94, 85.33, 10.32)
10:45940966	rs559240229	G>A	B:618	(4.30, 81.80, 15.56)
10:45940968		M>V	B:619	(0.81, 84.46, 14.04)
10:45940969	COSM539001	M>T	B:619	(0.81, 84.46, 14.04)
10:45940972		Y>F	B:620	(1.84, 81.04, 19.22)
10:45940988		F>L	B:625	(3.09, 79.10, 27.35)
10:45940992		E>K	B:627	(5.23, 82.34, 32.46)
10:45941005		K>R	B:631	(4.91, 86.16, 27.21)
10:45941007		E>K	B:632	(11.18, 86.76, 26.30)
10:45941020		R>Q	B:636	(14.43, 85.07, 21.83)
10:45941025		R>C	B:638	(6.84, 85.77, 17.46)
10:45941026	COSM3415053	R>H	B:638	(6.84, 85.77, 17.46)
10:45941044		I>T	B:644	(13.71, 82.09, 7.80)
10:45941050		S>I	B:646	(13.94, 88.24, 4.45)
10:45941058		A>T	B:649	(12.32, 87.12, -0.26)
10:45941061		E>K	B:650	(17.13, 88.27, -1.26)
10:45941065	COSM1182584	R>H	B:651	(15.60, 81.91, -2.68)
10:45941076	rs140481567	K>Q	B:655	(14.46, 81.84, -8.25)
10:45941080		Q>L	B:656	(13.49, 81.31, -14.14)
10:45941091		Y>H	B:660	(5.68, 81.09, -3.07)
10:45941109		R>W	B:666	(2.59, 82.28, 1.80)
10:45941110	COSM4014269	R>Q	B:666	(2.59, 82.28, 1.80)
10:45941116		P>L	B:668	(-0.26, 77.23, 7.96)
10:45941130		I>V	B:673	(-7.10, 73.05, 4.47)

3O8Y.B | ALOX5.

3O8Y.B | ALOX5

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:45877960	COSM1957783	E>D	B:59	(-14.74, 82.67, 53.74)
10:45877970	COSM3415050	E>K	B:63	(-2.80, 81.17, 47.00)
10:45878049	COSM1505458	T>M	B:89	(-6.64, 88.75, 44.57)
10:45878069	COSM3726890	E>K	B:96	(-4.09, 84.99, 33.50)
10:45878099	COSM1702290	D>N	B:106	(-22.51, 68.91, 29.31)
10:45878105	COSM342079	E>K	B:108	(-17.82, 72.13, 36.68)
10:45891350	COSM1603461	R>S	B:132	(-6.25, 61.02, 40.02)
10:45891369	COSM1702291	R>Q	B:138	(-7.78, 65.91, 28.60)
10:45907676	COSM278791	D>N	B:156	(-13.37, 57.21, 18.98)
10:45907730	COSM3437915	G>R	B:174	(-16.72, 75.76, 8.54)
10:45920488	COSM84003	R>C	B:247	(23.02, 60.74, -4.48)
10:45920489	COSM216253	R>H	B:247	(23.02, 60.74, -4.48)
10:45924111	COSM918275	D>N	B:293	(-6.67, 48.07, -6.56)
10:45935921	COSM918277	S>L	B:341	(15.20, 59.94, -28.30)
10:45936008	COSM189247	R>Q	B:370	(4.99, 60.67, 5.53)
10:45938582	COSM1957810	A>T	B:456	(18.38, 59.52, 3.68)
10:45941026	COSM3415053	R>H	B:638	(6.84, 85.77, 17.46)
10:45941065	COSM1182584	R>H	B:651	(15.60, 81.91, -2.68)
10:45941115	COSM1347876	P>S	B:668	(-0.26, 77.23, 7.96)