General Structure Information
| PDB ID | 1b0f |
| HGNC Gene Label(s) | ELANE |
| Structure Name | crystal structure of human neutrophil elastase with mdl 101, 146 |
| Resolution | 3.0Å |
| Reference | AUTH R.J.CREGGE,S.L.DURHAM,R.A.FARR,S.L.GALLION,C.M.HARE,AUTH 2 R.V.HOFFMAN,M.J.JANUSZ,H.O.KIM,J.R.KOEHL,S.MEHDI,W.A.METZ,AUTH 3 N.P.PEET,J.T.PELTON,H.A.SCHREUDER,S.SUNDER,C.TARDIFTITL INHIBITION OF HUMAN NEUTROPHIL ELASTASE. 4. DESIGN,TITL 2 SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, ANDTITL 3 STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OFTITL 4 P2-MODIFIED, ORALLY ACTIVE PEPTIDYL PENTAFLUOROETHYLTITL 5 KETONES.REF J.MED.CHEM. V. 41 2461 1998REFN ISSN 0022-2623PMID 9651152DOI 10.1021/JM970812E |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 210 |
| Number Of SNVs | 67 |
| Number Of Permutations | 5890 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.133 |
| p-value | 0.381 |
ClinVar
| Number Of Residues | 210 |
| Number Of SNVs | 10 |
| Number Of Permutations | 833 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.178 |
| p-value | 0.492 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of ClinVar SNVs | 10 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.034 |
| p-value | 0.375 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
