General Structure Information
| PDB ID | 4i0p |
| HGNC Gene Label(s) | HLA-DOA |
| Structure Name | hla-do in complex with hla-dm |
| Resolution | 3.2Å |
| Reference | AUTH A.I.GUCE,S.E.MORTIMER,T.YOON,C.A.PAINTER,W.JIANG,AUTH 2 E.D.MELLINS,L.J.STERNTITL HLA-DO ACTS AS A SUBSTRATE MIMIC TO INHIBIT HLA-DM BY ATITL 2 COMPETITIVE MECHANISM.REF NAT.STRUCT.MOL.BIOL. V. 20 90 2013REFN ISSN 1545-9993PMID 23222639DOI 10.1038/NSMB.2460 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 180 |
| Number Of SNVs | 53 |
| Number Of Permutations | 26501 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.028 |
| p-value | 0.61 |
COSMIC
| Number Of Residues | 180 |
| Number Of SNVs | 4 |
| Number Of Permutations | 194 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.167 |
| p-value | 0.958 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.279 |
| p-value | 0.946 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
