1KSN.B | F10

General Structure Information

PDB ID 1ksn
HGNC Gene Label(s) F10
Structure Name crystal structure of human coagulation factor xa complexed with fxv673
Resolution 2.1Å
Reference AUTH K.R.GUERTIN,C.J.GARDNER,S.I.KLEIN,A.L.ZULLI,AUTH 2 M.CZEKAJ,Y.GONG,A.P.SPADA,D.L.CHENEY,S.MAIGNAN,AUTH 3 J.P.GUILLOTEAU,K.D.BROWN,D.J.COLUSSI,V.CHU,AUTH 4 C.L.HERAN,S.R.MORGAN,R.G.BENTLEY,C.T.DUNWIDDIE,AUTH 5 R.J.LEADLEY,H.W.PAULSTITL OPTIMIZATION OF THE BETA-AMINOESTER CLASS OFTITL 2 FACTOR XA INHIBITORS. PART 2: IDENTIFICATION OFTITL 3 FXV673 AS A POTENT AND SELECTIVE INHIBITOR WITHTITL 4 EXCELLENT IN VIVO ANTICOAGULANT ACTIVITY.REF BIOORG.MED.CHEM.LETT. V. 12 1671 2002REFN ISSN 0960-894XPMID 12039587DOI 10.1016/S0960-894X(02)00213-5

Variant Set Distributions

ExAC Variants

Number Of Residues 50
Number Of SNVs 11
Number Of Permutations 4312
Optimal Distance Threshold 13.0
K Statistic 0.345
p-value 0.63

Mapped Variants

[+] ExAC Missense Variants