General Structure Information
| PDB ID | 2xn5 |
| HGNC Gene Label(s) | SERPINA7 |
| Structure Name | crystal structure of thyroxine-binding globulin complexed with furosemide |
| Resolution | 1.7Å |
| Reference | AUTH X.QI,F.LOISEAU,W.L.CHAN,Y.YAN,Z.WEI,L.G.MILROY,AUTH 2 R.M.MYERS,S.V.LEY,R.J.READ,R.W.CARRELL,A.ZHOUTITL ALLOSTERIC MODULATION OF HORMONE RELEASE FROMTITL 2 THYROXINE AND CORTICOSTEROID BINDING-GLOBULINS.REF J.BIOL.CHEM. V. 286 16163 2011REFN ISSN 0021-9258PMID 21325280DOI 10.1074/JBC.M110.171082 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 342 |
| Number Of SNVs | 70 |
| Number Of Permutations | 11761 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.019 |
| p-value | 0.479 |
ClinVar
| Number Of Residues | 342 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1197 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.0 |
| p-value | 0.993 |
COSMIC
| Number Of Residues | 342 |
| Number Of SNVs | 10 |
| Number Of Permutations | 2300 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.022 |
| p-value | 0.078 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 70 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.109 |
| p-value | 0.897 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 70 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.046 |
| p-value | 0.148 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
