1AU1.B | IFNB1

General Structure Information

PDB ID	1au1
HGNC Gene Label(s)	IFNB1
Structure Name	human interferon-beta crystal structure
Resolution	2.2Å
Reference	AUTH M.KARPUSAS,M.NOLTE,C.B.BENTON,W.MEIER,W.N.LIPSCOMB,AUTH 2 S.GOELZTITL THE CRYSTAL STRUCTURE OF HUMAN INTERFERON BETA ATTITL 2 2.2-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 94 11813 1997REFN ISSN 0027-8424PMID 9342320DOI 10.1073/PNAS.94.22.11813

Variant Set Distributions

ExAC Variants

Number Of Residues	163
Number Of SNVs	45
Number Of Permutations	6511
Optimal Distance Threshold	12.0
K Statistic	0.118
p-value	0.057

COSMIC

Number Of Residues	163
Number Of SNVs	3
Number Of Permutations	1
Optimal Distance Threshold	7.0
K Statistic	0.333
p-value	1.0

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:21077804		M>K	B:1	(19.21, 43.15, 22.74)
9:21077801		S>T	B:2	(18.18, 41.43, 26.53)
9:21077799	rs149697542	Y>H	B:3	(16.31, 45.75, 27.68)
9:21077789		L>R	B:6	(13.99, 41.88, 30.73)
9:21077780		L>P	B:9	(11.16, 37.88, 32.49)
9:21077773	rs189075512	R>S	B:11	(6.02, 41.33, 29.77)
9:21077771		S>I	B:12	(5.91, 37.28, 34.44)
9:21077756	rs369178137	C>Y	B:17	(3.73, 40.07, 42.42)
9:21077754		Q>E	B:18	(0.36, 42.62, 40.41)
9:21077749		K>N	B:19	(-2.44, 36.28, 40.94)
9:21077740	rs571602165	W>C	B:22	(-4.72, 43.05, 44.78)
9:21077742		W>G	B:22	(-4.72, 43.05, 44.78)
9:21077730	rs200614912	G>R	B:26	(-6.91, 39.24, 57.09)
9:21077711		L>P	B:32	(-5.30, 53.89, 62.71)
9:21077695		N>K	B:37	(0.08, 61.44, 51.29)
9:21077689	rs34130181	D>E	B:39	(4.70, 62.32, 49.60)
9:21077670	rs202048292	Q>K	B:46	(8.02, 61.99, 36.72)
9:21077664		Q>E	B:48	(8.93, 60.71, 32.01)
9:21077659		Q>H	B:49	(9.36, 57.91, 26.07)
9:21077643	rs142435111	A>T	B:55	(13.07, 52.14, 32.85)
9:21077640	rs146710785	A>T	B:56	(15.00, 49.69, 34.21)
9:21077625	COSM3664284	E>K	B:61	(15.81, 52.14, 41.84)
9:21077620		M>I	B:62	(10.79, 50.77, 42.51)
9:21077621		M>T	B:62	(10.79, 50.77, 42.51)
9:21077601		I>V	B:69	(9.35, 47.04, 52.60)
9:21077594		R>T	B:71	(14.93, 41.45, 53.90)
9:21077591	rs199747150	Q>R	B:72	(11.09, 44.56, 57.37)
9:21077589	rs181238596	D>N	B:73	(7.91, 41.72, 61.35)
9:21077569		W>C	B:79	(-0.79, 39.70, 55.81)
9:21077565	COSM608491	E>K	B:81	(4.09, 33.51, 56.92)
9:21077561		T>I	B:82	(3.65, 30.81, 52.65)
9:21077547	rs149609099	L>F	B:87	(6.13, 38.28, 47.24)
9:21077543		L>P	B:88	(9.79, 38.24, 49.15)
9:21077528	rs200392542	H>R	B:93	(14.39, 35.58, 40.24)
9:21077518	rs565286379	N>K	B:96	(19.11, 38.71, 39.19)
9:21077511		K>E	B:99	(22.64, 42.63, 39.46)
9:21077489		L>R	B:106	(27.23, 49.84, 33.82)
9:21077477		D>G	B:110	(26.38, 59.45, 32.09)
9:21077471	rs189255883	T>I	B:112	(22.48, 62.36, 35.39)
9:21077465	COSM3413557 COSM3656525	G>E	B:114	(18.37, 63.13, 36.99)
9:21077455	COSM753786	M>I	B:117	(17.45, 64.18, 42.07)
9:21077456		M>T	B:117	(17.45, 64.18, 42.07)
9:21077451		S>R	B:119	(18.10, 57.73, 43.62)
9:21077439		K>E	B:123	(17.91, 56.09, 47.59)
9:21077415	COSM1461746	H>Y	B:131	(9.67, 56.54, 60.07)
9:21077408	rs139325335	L>R	B:133	(6.24, 50.35, 59.13)
9:21077378		W>L	B:143	(2.83, 45.69, 57.34)
9:21077371	rs141894933	I>M	B:145	(-1.64, 51.53, 55.27)

1AU1.B | IFNB1.

1AU1.B | IFNB1

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:21077649	COSM3091865	E>K	B:53	(18.04, 52.22, 29.21)
9:21077640	COSM2154341	A>T	B:56	(15.00, 49.69, 34.21)
9:21077465	COSM3413557	G>V	B:114	(18.37, 63.13, 36.99)