General Structure Information
| PDB ID | 4iu7 |
| HGNC Gene Label(s) | ESR1 |
| Structure Name | crystal structure of the estrogen receptor alpha ligand-binding domain in complex with constrained way-derivative, 2b |
| Resolution | 2.29Å |
| Reference | AUTH S.SRINIVASAN,J.C.NWACHUKWU,A.A.PARENT,V.CAVETT,J.NOWAK,AUTH 2 T.S.HUGHES,D.J.KOJETIN,J.A.KATZENELLENBOGEN,K.W.NETTLESTITL LIGAND BINDING DYNAMICS REWIRE CELLULAR SIGNALING VIATITL 2 ESTROGEN RECEPTOR-ALPHAREF NAT.CHEM.BIOL. V. 9 326 2013REFN ISSN 1552-4450PMID 23524984DOI 10.1038/NCHEMBIO.1214 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 237 |
| Number Of SNVs | 32 |
| Number Of Permutations | 16399 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.264 |
| p-value | 0.243 |
COSMIC
| Number Of Residues | 237 |
| Number Of SNVs | 7 |
| Number Of Permutations | 770 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.095 |
| p-value | 0.071 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 32 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.032 |
| p-value | 0.706 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
