General Structure Information
| PDB ID | 3zqk |
| HGNC Gene Label(s) | VWF |
| Structure Name | von willebrand factor a2 domain with calcium |
| Resolution | 1.7Å |
| Reference | AUTH A.J.JAKOBI,A.MASHAGHI,S.J.TANS,E.G.HUIZINGATITL CALCIUM MODULATES FORCE SENSING BY THE VON WILLEBRANDTITL 2 FACTOR A2 DOMAIN.REF NAT.COMMUN. V. 2 385 2011REFN ISSN 2041-1723PMID 21750539DOI 10.1038/NCOMMS1385 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 178 |
| Number Of SNVs | 31 |
| Number Of Permutations | 7570 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.127 |
| p-value | 0.097 |
ClinVar
| Number Of Residues | 178 |
| Number Of SNVs | 5 |
| Number Of Permutations | 597 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.2 |
| p-value | 0.356 |
COSMIC
| Number Of Residues | 178 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1459 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.2 |
| p-value | 0.477 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.158 |
| p-value | 0.07 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.145 |
| p-value | 0.558 |