General Structure Information
| PDB ID | 3rcd |
| HGNC Gene Label(s) | ERBB2 |
| Structure Name | her2 kinase domain complexed with tak-285 |
| Resolution | 3.21Å |
| Reference | AUTH T.ISHIKAWA,M.SETO,H.BANNO,Y.KAWAKITA,M.OORUI,T.TANIGUCHI,AUTH 2 Y.OHTA,T.TAMURA,A.NAKAYAMA,H.MIKI,H.KAMIGUCHI,T.TANAKA,AUTH 3 N.HABUKA,S.SOGABE,J.YANO,K.AERTGEERTS,K.KAMIYAMATITL DESIGN AND SYNTHESIS OF NOVEL HUMAN EPIDERMAL GROWTH FACTORTITL 2 RECEPTOR 2 (HER2)/EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)TITL 3 DUAL INHIBITORS BEARING A PYRROLO[3,2-D]PYRIMIDINE SCAFFOLD.REF J.MED.CHEM. V. 54 8030 2011REFN ISSN 0022-2623PMID 22003817DOI 10.1021/JM2008634 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 278 |
| Number Of SNVs | 40 |
| Number Of Permutations | 6447 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.221 |
| p-value | 0.012 |
ClinVar
| Number Of Residues | 278 |
| Number Of SNVs | 4 |
| Number Of Permutations | 447 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.0 |
| p-value | 0.274 |
COSMIC
| Number Of Residues | 278 |
| Number Of SNVs | 15 |
| Number Of Permutations | 2183 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.019 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | -0.158 |
| p-value | 0.56 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of COSMIC SNVs | 13 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.215 |
| p-value | 0.136 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
