General Structure Information
| PDB ID | 2y3i |
| HGNC Gene Label(s) | PGK1 |
| Structure Name | the structure of the fully closed conformation of human pgk in complex with l-adp, 3pg and the tsa aluminium tetrafluoride |
| Resolution | 2.9Å |
| Reference | AUTH P.LALLEMAND,L.CHALOIN,B.ROY,T.BARMAN,M.W.BOWLER,C.LIONNETITL INTERACTION OF HUMAN 3-PHOSPHOGLYCERATE KINASE WITH ITS TWOTITL 2 SUBSTRATES: IS SUBSTRATE ANTAGONISM A KINETIC ADVANTAGE?REF J.MOL.BIOL. V. 409 742 2011REFN ISSN 0022-2836PMID 21549713DOI 10.1016/J.JMB.2011.04.048 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 414 |
| Number Of SNVs | 83 |
| Number Of Permutations | 40820 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.257 |
| p-value | 0.268 |
ClinVar
| Number Of Residues | 414 |
| Number Of SNVs | 13 |
| Number Of Permutations | 6483 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.051 |
| p-value | 0.387 |
COSMIC
| Number Of Residues | 414 |
| Number Of SNVs | 4 |
| Number Of Permutations | 252 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.167 |
| p-value | 0.471 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of ClinVar SNVs | 13 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.042 |
| p-value | 0.275 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 83 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.107 |
| p-value | 0.691 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
