General Structure Information
| PDB ID | 4gj7 |
| HGNC Gene Label(s) | REN |
| Structure Name | crystal structure of renin in complex with nvp-bca079 (compound 12a) |
| Resolution | 2.8Å |
| Reference | AUTH E.LORTHIOIS,W.BREITENSTEIN,F.CUMIN,C.EHRHARDT,E.FRANCOTTE,AUTH 2 E.JACOBY,N.OSTERMANN,H.SELLNER,T.KOSAKA,R.L.WEBB,D.F.RIGEL,AUTH 3 U.HASSIEPEN,P.RICHERT,T.WAGNER,J.MAIBAUMTITL THE DISCOVERY OF NOVEL POTENT TRANS-3,4-DISUBSTITUTEDTITL 2 PYRROLIDINE INHIBITORS OF THE HUMAN ASPARTIC PROTEASE RENINTITL 3 FROM IN SILICO THREE-DIMENSIONAL (3D) PHARMACOPHORETITL 4 SEARCHES.REF J.MED.CHEM. V. 56 2207 2013REFN ISSN 0022-2623PMID 23425156DOI 10.1021/JM3017078 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 323 |
| Number Of SNVs | 76 |
| Number Of Permutations | 10632 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.113 |
| p-value | 0.012 |
COSMIC
| Number Of Residues | 323 |
| Number Of SNVs | 7 |
| Number Of Permutations | 2975 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.571 |
| p-value | 0.088 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 76 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.448 |
| p-value | 0.026 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
