General Structure Information
| PDB ID | 1m6i |
| HGNC Gene Label(s) | AIFM1 |
| Structure Name | crystal structure of apoptosis inducing factor (aif) |
| Resolution | 1.8Å |
| Reference | AUTH H.YE,C.CANDE,N.C.STEPHANOU,S.JIANG,S.GURBUXANI,AUTH 2 N.LAROCHETTE,E.DAUGAS,C.GARRIDO,G.KROEMER,H.WUTITL DNA BINDING IS REQUIRED FOR THE APOPTOGENIC ACTIONTITL 2 OF APOPTOSIS INDUCING FACTOR.REF NAT.STRUCT.BIOL. V. 9 680 2002REFN ISSN 1072-8368PMID 12198487DOI 10.1038/NSB836 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 459 |
| Number Of SNVs | 46 |
| Number Of Permutations | 8158 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.207 |
| p-value | 0.074 |
ClinVar
| Number Of Residues | 459 |
| Number Of SNVs | 14 |
| Number Of Permutations | 2395 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.0 |
| p-value | 0.444 |
COSMIC
| Number Of Residues | 459 |
| Number Of SNVs | 4 |
| Number Of Permutations | 273 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.167 |
| p-value | 0.819 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of ClinVar SNVs | 14 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | -0.017 |
| p-value | 0.834 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.169 |
| p-value | 1.0 |