General Structure Information
| PDB ID | 4f0i |
| HGNC Gene Label(s) | NTRK1 |
| Structure Name | crystal structure of apo trka |
| Resolution | 2.3Å |
| Reference | AUTH T.BERTRAND,M.KOTHE,J.LIU,A.DUPUY,A.RAK,P.F.BERNE,S.DAVIS,AUTH 2 T.GLADYSHEVA,C.VALTRE,J.Y.CRENNE,M.MATHIEUTITL THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONSTITL 2 FOR ACHIEVING SELECTIVE INHIBITION.REF J.MOL.BIOL. V. 423 439 2012REFN ISSN 0022-2836PMID 22902478DOI 10.1016/J.JMB.2012.08.002 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 284 |
| Number Of SNVs | 73 |
| Number Of Permutations | 9192 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.223 |
| p-value | 0.08 |
ClinVar
| Number Of Residues | 284 |
| Number Of SNVs | 9 |
| Number Of Permutations | 1110 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.139 |
| p-value | 0.782 |
COSMIC
| Number Of Residues | 284 |
| Number Of SNVs | 10 |
| Number Of Permutations | 3135 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.022 |
| p-value | 0.567 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 73 |
| Number Of ClinVar SNVs | 9 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.057 |
| p-value | 0.933 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 73 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.021 |
| p-value | 0.323 |