General Structure Information
| PDB ID | 3t2n |
| HGNC Gene Label(s) | HPN |
| Structure Name | human hepsin protease in complex with the fab fragment of an inhibitory antibody |
| Resolution | 2.55Å |
| Reference | AUTH T.KOSCHUBS,S.DENGL,H.DURR,K.KALUZA,G.GEORGES,C.HARTL,AUTH 2 S.JENNEWEIN,M.LANZENDORFER,J.AUER,A.STERN,K.S.HUANG,AUTH 3 K.PACKMAN,U.GUBLER,D.KOSTREWA,S.RIES,S.HANSEN,U.KOHNERT,AUTH 4 P.CRAMER,O.MUNDIGLTITL ALLOSTERIC ANTIBODY INHIBITION OF HUMAN HEPSIN PROTEASE.REF BIOCHEM.J. V. 442 483 2012REFN ISSN 0264-6021PMID 22132769DOI 10.1042/BJ20111317 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 339 |
| Number Of SNVs | 68 |
| Number Of Permutations | 13724 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.17 |
| p-value | 0.01 |
COSMIC
| Number Of Residues | 339 |
| Number Of SNVs | 9 |
| Number Of Permutations | 4829 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.444 |
| p-value | 0.358 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 68 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.189 |
| p-value | 0.169 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
