General Structure Information
| PDB ID | 3k71 |
| HGNC Gene Label(s) | ITGB2 |
| Structure Name | structure of integrin alphax beta2 ectodomain |
| Resolution | 3.95Å |
| Reference | AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 673 |
| Number Of SNVs | 203 |
| Number Of Permutations | 54645 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.05 |
| p-value | 0.007 |
ClinVar
| Number Of Residues | 673 |
| Number Of SNVs | 13 |
| Number Of Permutations | 4731 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.551 |
| p-value | 0.001 |
COSMIC
| Number Of Residues | 673 |
| Number Of SNVs | 12 |
| Number Of Permutations | 15143 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.045 |
| p-value | 0.779 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 203 |
| Number Of ClinVar SNVs | 12 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.379 |
| p-value | 0.001 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 203 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | -0.114 |
| p-value | 0.902 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 21:46330266 | rs568718880 | K>R | D:5 | (62.27, 27.22, 77.88) |
| 21:46330254 | rs550553324 | S>N | D:9 | (69.46, 35.89, 77.37) |
| 21:46330245 | rs140032296 | R>Q | D:12 | (71.41, 35.10, 86.30) |
| 21:46330242 | E>G | D:13 | (67.70, 34.73, 81.79) | |
| 21:46330239 | C>Y | D:14 | (68.26, 29.09, 82.53) | |
| 21:46330230 | rs368899902 | S>L | D:17 | (63.67, 28.75, 84.97) |
| 21:46330227 | G>A | D:18 | (64.60, 26.19, 87.65) | |
| 21:46330216 | T>P | D:22 | (70.47, 22.71, 82.77) | |
| 21:46327010 | rs199810704 | N>Y | D:28 | (79.80, 25.16, 67.55) |
| 21:46326998 | rs200341907 | P>T | D:32 | (72.20, 26.10, 61.18) |
| 21:46326995 | G>R | D:33 | (68.94, 27.92, 62.87) | |
| 21:46326992 | D>N | D:34 | (69.02, 26.36, 65.83) | |
| 21:46326976 | R>H | D:39 | (72.93, 26.77, 74.24) | |
| 21:46326977 | rs375038257 | R>C | D:39 | (72.93, 26.77, 74.24) |
| 21:46326971 | D>N | D:41 | (66.81, 21.29, 78.54) | |
| 21:46326967 | T>N | D:42 | (67.01, 18.73, 81.00) | |
| 21:46326964 | rs144806686 | R>Q | D:43 | (71.65, 15.87, 83.54) |
| 21:46326965 | R>W | D:43 | (71.65, 15.87, 83.54) | |
| 21:46326962 | P>T | D:44 | (68.93, 14.63, 80.72) | |
| 21:46326950 | M>L | D:48 | (69.58, 12.78, 74.18) | |
| 21:46326945 | rs371854500 | R>S | D:49 | (70.16, 18.06, 71.90) |
| 21:46326937 | rs201354221 COSM3405470 |
A>V | D:52 | (78.82, 17.85, 77.44) |
| 21:46326938 | A>S | D:52 | (78.82, 17.85, 77.44) | |
| 21:46326932 | rs551980142 | D>N | D:54 | (82.31, 19.07, 80.96) |
| 21:46326926 | I>V | D:56 | (76.11, 20.73, 82.16) | |
| 21:46326905 | rs548099370 COSM1031392 |
A>T | D:63 | (76.98, 24.01, 103.38) |
| 21:46326898 | T>S | D:65 | (80.45, 23.70, 108.47) | |
| 21:46326892 | E>A | D:67 | (83.20, 23.32, 113.19) | |
| 21:46326883 | N>S | D:70 | (85.58, 24.17, 122.62) | |
| 21:46326881 | G>R | D:71 | (83.40, 27.34, 124.21) | |
| 21:46326877 | G>A | D:72 | (81.94, 29.05, 122.30) | |
| 21:46326856 | Q>R | D:79 | (78.98, 27.03, 116.00) | |
| 21:46326847 | rs138682103 | T>M | D:82 | (78.01, 30.17, 105.30) |
| 21:46326844 | rs145851783 | L>P | D:83 | (73.72, 29.40, 103.28) |
| 21:46326835 | rs550007417 | R>Q | D:86 | (69.68, 27.77, 92.46) |
| 21:46323444 | rs374494108 | A>V | D:90 | (67.49, 23.18, 99.07) |
| 21:46323445 | A>P | D:90 | (67.49, 23.18, 99.07) | |
| 21:46323442 | rs141700802 | A>T | D:91 | (69.92, 23.99, 101.79) |
| 21:46323430 | V>M | D:95 | (71.86, 20.65, 114.18) | |
| 21:46323426 | T>N | D:96 | (74.75, 18.39, 116.76) | |
| 21:46323424 | F>V | D:97 | (71.53, 19.80, 121.50) | |
| 21:46323420 | rs371519127 | R>Q | D:98 | (76.44, 16.37, 123.83) |
| 21:46323421 | rs148031841 | R>W | D:98 | (76.44, 16.37, 123.83) |
| 21:46323414 | A>V | D:100 | (75.08, 18.21, 129.74) | |
| 21:46323402 | P>H | D:104 | (73.35, 27.93, 137.62) | |
| 21:46323387 | Y>S | D:109 | (56.22, 30.30, 144.99) | |
| 21:46323379 | D>N | D:112 | (47.18, 34.06, 144.65) | |
| 21:46323363 | M>T | D:117 | (45.78, 30.65, 148.65) | |
| 21:46323364 | M>V | D:117 | (45.78, 30.65, 148.65) | |
| 21:46323360 | L>H | D:118 | (44.39, 30.84, 153.85) | |
| 21:46323358 | D>H | D:119 | (45.32, 26.04, 153.09) | |
| 21:46323325 | COSM1031388 | D>Y | D:130 | (62.41, 20.98, 150.96) |
| 21:46323315 | R>Q | D:133 | (67.26, 18.53, 151.33) | |
| 21:46323310 | L>F | D:135 | (68.86, 22.50, 144.31) | |
| 21:46323304 | E>K | D:137 | (69.97, 16.50, 143.99) | |
| 21:46323295 | rs577751727 | E>K | D:140 | (75.93, 24.17, 142.59) |
| 21:46323289 | G>S | D:142 | (71.50, 28.75, 143.85) | |
| 21:46323285 | R>H | D:143 | (70.70, 32.66, 143.57) | |
| 21:46323286 | R>C | D:143 | (70.70, 32.66, 143.57) | |
| 21:46323282 | I>T | D:144 | (65.80, 31.18, 146.39) | |
| 21:46323283 | I>V | D:144 | (65.80, 31.18, 146.39) | |
| 21:46321622 | V>M | D:154 | (40.78, 49.45, 140.46) | |
| 21:46321618 | L>P | D:155 | (36.78, 48.99, 140.16) | |
| 21:46321615 | rs137852614 | P>L | D:156 | (35.69, 45.91, 138.44) |
| 21:46321610 | rs574757270 COSM1414461 |
V>M | D:158 | (38.63, 45.10, 144.22) |
| 21:46321603 | rs201354969 | T>M | D:160 | (37.85, 50.91, 145.44) |
| 21:46321598 | rs367806842 | P>S | D:162 | (35.34, 51.75, 151.73) |
| 21:46321573 | rs375117940 COSM272822 |
P>L | D:170 | (36.52, 37.54, 154.65) |
| 21:46321567 | K>R | D:172 | (38.29, 34.96, 159.97) | |
| 21:46321559 | E>K | D:175 | (45.37, 42.51, 160.66) | |
| 21:46321549 | P>L | D:178 | (46.67, 45.69, 152.27) | |
| 21:46321550 | P>S | D:178 | (46.67, 45.69, 152.27) | |
| 21:46321546 | rs372179082 CD078444 |
P>L | D:179 | (44.31, 45.39, 148.96) |
| 21:46321534 | rs368225700 | R>T | D:183 | (54.70, 43.47, 148.96) |
| 21:46321523 | K>Q | D:187 | (66.77, 39.72, 145.76) | |
| 21:46321514 | rs376609171 | N>D | D:190 | (72.58, 32.44, 148.63) |
| 21:46321505 | N>D | D:193 | (66.81, 30.67, 156.99) | |
| 21:46321501 | Q>R | D:194 | (66.07, 35.28, 155.95) | |
| 21:46321486 | V>A | D:199 | (57.14, 34.38, 153.63) | |
| 21:46321484 | G>R | D:200 | (55.01, 34.53, 156.80) | |
| 21:46321468 | S>F | D:205 | (44.09, 39.75, 150.81) | |
| 21:46321418 | rs141195302 | A>T | D:222 | (60.63, 40.33, 133.86) |
| 21:46321414 | A>V | D:223 | (61.18, 44.12, 133.51) | |
| 21:46321415 | rs144280462 | A>T | D:223 | (61.18, 44.12, 133.51) |
| 21:46321408 | COSM478656 | P>L | D:225 | (66.20, 43.35, 136.68) |
| 21:46320381 | G>S | D:229 | (67.43, 40.82, 140.07) | |
| 21:46320368 | V>A | D:233 | (72.36, 31.32, 134.12) | |
| 21:46320369 | rs200206541 | V>I | D:233 | (72.36, 31.32, 134.12) |
| 21:46320365 | T>M | D:234 | (68.84, 29.78, 135.09) | |
| 21:46320363 | COSM3964021 | R>W | D:235 | (66.40, 34.14, 134.36) |
| 21:46320347 | A>D | D:240 | (50.24, 29.77, 141.99) | |
| 21:46320336 | G>S | D:244 | (42.44, 32.79, 137.22) | |
| 21:46320327 | rs151274588 | F>L | D:247 | (43.14, 38.20, 129.18) |
| 21:46320323 | rs147318988 | A>V | D:248 | (44.13, 42.23, 127.72) |
| 21:46320324 | rs148775158 | A>T | D:248 | (44.13, 42.23, 127.72) |
| 21:46320318 | D>N | D:250 | (39.90, 42.65, 130.92) | |
| 21:46320314 | G>E | D:251 | (40.75, 47.26, 131.50) | |
| 21:46320315 | rs137852618 | G>R | D:251 | (40.75, 47.26, 131.50) |
| 21:46320306 | G>S | D:254 | (38.75, 50.52, 134.56) | |
| 21:46320303 | COSM725840 COSM4102021 |
A>T | D:255 | (38.97, 53.20, 132.85) |
| 21:46320298 | I>M | D:256 | (42.37, 51.26, 132.02) | |
| 21:46320296 | L>P | D:257 | (41.97, 52.55, 127.26) | |
| 21:46320287 | N>S | D:260 | (51.87, 46.44, 128.40) | |
| 21:46320285 | rs149483341 | D>N | D:261 | (55.05, 49.13, 128.87) |
| 21:46320282 | rs137852616 | G>S | D:262 | (56.96, 46.14, 129.72) |
| 21:46320278 | R>H | D:263 | (60.60, 48.97, 130.23) | |
| 21:46320267 | E>K | D:267 | (59.60, 53.66, 145.24) | |
| 21:46320240 | rs368371881 | E>K | D:276 | (48.02, 54.13, 136.37) |
| 21:46319070 | P>L | D:280 | (49.42, 41.89, 130.19) | |
| 21:46319067 | S>L | D:281 | (48.97, 40.41, 126.09) | |
| 21:46319057 | rs541510772 | Q>H | D:284 | (53.13, 41.20, 126.01) |
| 21:46319052 | rs370342954 | A>V | D:286 | (56.21, 34.42, 124.73) |
| 21:46319020 | rs199639864 | I>V | D:297 | (56.33, 25.75, 136.37) |
| 21:46319014 | rs377140902 | A>T | D:299 | (50.68, 25.02, 139.53) |
| 21:46319005 | rs140355034 | S>R | D:302 | (41.92, 20.22, 139.04) |
| 21:46319001 | R>K | D:303 | (39.08, 25.11, 139.24) | |
| 21:46319002 | R>G | D:303 | (39.08, 25.11, 139.24) | |
| 21:46318996 | V>L | D:305 | (44.44, 21.51, 134.70) | |
| 21:46318984 | E>K | D:309 | (47.14, 21.80, 128.88) | |
| 21:46314966 | COSM1031376 | E>K | D:313 | (49.80, 23.74, 123.30) |
| 21:46314951 | S>A | D:318 | (55.23, 25.00, 129.78) | |
| 21:46314945 | COSM1307887 | V>M | D:320 | (50.82, 20.89, 133.44) |
| 21:46314942 | G>R | D:321 | (50.13, 20.85, 137.75) | |
| 21:46314907 | rs235330 | Q>H | D:332 | (56.10, 15.83, 143.13) |
| 21:46314899 | rs530620955 | K>R | D:335 | (60.66, 14.89, 139.70) |
| 21:46313426 | A>T | D:351 | (61.70, 36.76, 112.12) | |
| 21:46313417 | rs371120443 | D>N | D:354 | (58.70, 37.68, 102.95) |
| 21:46313399 | Y>H | D:360 | (63.55, 23.24, 111.26) | |
| 21:46313378 | rs372510204 COSM3551548 |
G>R | D:367 | (62.35, 6.12, 117.65) |
| 21:46313371 | rs141201564 | T>M | D:369 | (61.57, 8.76, 112.28) |
| 21:46313336 | V>M | D:381 | (65.83, 14.10, 125.03) | |
| 21:46313330 | I>V | D:383 | (71.48, 14.07, 130.46) | |
| 21:46313325 | N>K | D:384 | (74.94, 12.65, 127.29) | |
| 21:46313320 | COSM2155053 | P>L | D:386 | (72.91, 13.10, 121.11) |
| 21:46311889 | rs113084585 | T>M | D:394 | (64.26, 27.51, 100.57) |
| 21:46311890 | T>A | D:394 | (64.26, 27.51, 100.57) | |
| 21:46311878 | C>R | D:398 | (67.65, 36.35, 94.11) | |
| 21:46311867 | E>D | D:401 | (74.50, 39.51, 101.72) | |
| 21:46311862 | rs375122306 | S>L | D:403 | (71.84, 37.69, 108.61) |
| 21:46311850 | COSM3551547 | R>Q | D:407 | (67.55, 31.34, 119.87) |
| 21:46311851 | COSM189200 | R>W | D:407 | (67.55, 31.34, 119.87) |
| 21:46311847 | COSM2153318 | A>V | D:408 | (67.20, 27.55, 121.60) |
| 21:46311835 | rs147537677 | T>R | D:412 | (72.24, 32.00, 125.55) |
| 21:46311830 | rs142489611 | I>V | D:414 | (73.39, 33.22, 119.31) |
| 21:46311827 | V>M | D:415 | (73.50, 30.09, 115.59) | |
| 21:46311821 | rs372056902 COSM1211037 |
V>M | D:417 | (72.90, 31.51, 109.96) |
| 21:46311816 | rs138703739 | Q>H | D:418 | (76.26, 34.04, 106.37) |
| 21:46311815 | V>F | D:419 | (72.41, 34.13, 103.85) | |
| 21:46311812 | rs144483210 | L>F | D:420 | (75.43, 33.97, 100.74) |
| 21:46311793 | rs149279736 | R>Q | D:426 | (82.32, 29.85, 87.80) |
| 21:46311787 | R>Q | D:428 | (84.96, 31.25, 79.60) | |
| 21:46311781 | Q>R | D:430 | (85.50, 40.73, 77.89) | |
| 21:46311778 | rs138659490 | S>N | D:431 | (89.75, 37.86, 77.19) |
| 21:46311769 | COSM88580 | R>H | D:434 | (88.25, 41.17, 72.53) |
| 21:46311770 | rs146014032 | R>C | D:434 | (88.25, 41.17, 72.53) |
| 21:46311755 | G>S | D:439 | (82.99, 42.90, 69.13) | |
| 21:46311734 | G>S | D:446 | (79.48, 30.39, 74.43) | |
| 21:46310120 | rs376491409 | I>T | D:455 | (70.76, 41.22, 68.93) |
| 21:46310121 | I>V | D:455 | (70.76, 41.22, 68.93) | |
| 21:46310087 | rs556160781 | R>L | D:466 | (68.29, 42.08, 59.36) |
| 21:46310088 | R>W | D:466 | (68.29, 42.08, 59.36) | |
| 21:46310079 | Q>E | D:469 | (63.23, 33.77, 51.76) | |
| 21:46310057 | rs369318947 COSM1414455 |
R>Q | D:476 | (56.57, 30.01, 60.15) |
| 21:46310051 | COSM444591 | D>G | D:478 | (53.72, 25.51, 61.90) |
| 21:46310049 | rs371797683 | N>D | D:479 | (54.45, 25.06, 57.42) |
| 21:46310044 | N>K | D:480 | (49.94, 26.10, 58.60) | |
| 21:46310035 | I>M | D:483 | (55.84, 35.07, 61.20) | |
| 21:46310007 | rs550491140 | G>R | D:493 | (65.37, 33.51, 62.57) |
| 21:46309983 | rs199976562 | D>N | D:501 | (53.38, 49.46, 78.74) |
| 21:46309979 | COSM444590 | V>D | D:502 | (50.80, 46.16, 80.71) |
| 21:46309980 | rs201654243 | V>I | D:502 | (50.80, 46.16, 80.71) |
| 21:46309974 | G>S | D:504 | (52.70, 41.57, 83.54) | |
| 21:46309958 | G>E | D:509 | (59.75, 32.76, 72.85) | |
| 21:46309925 | E>G | D:520 | (42.84, 29.11, 85.53) | |
| 21:46309923 | COSM1031370 | R>C | D:521 | (41.13, 35.10, 85.86) |
| 21:46309920 | rs201703437 | Y>H | D:522 | (41.46, 31.92, 93.12) |
| 21:46309902 | G>S | D:528 | (46.39, 33.92, 92.49) | |
| 21:46309895 | rs201000019 | P>L | D:530 | (51.07, 37.57, 93.68) |
| 21:46309402 | L>F | D:534 | (53.09, 32.84, 88.98) | |
| 21:46309380 | rs550704811 | R>H | D:541 | (55.50, 27.30, 88.05) |
| 21:46309381 | R>C | D:541 | (55.50, 27.30, 88.05) | |
| 21:46309371 | rs373223342 COSM224603 |
P>L | D:544 | (55.14, 26.53, 97.83) |
| 21:46309368 | G>D | D:545 | (51.25, 24.79, 99.27) | |
| 21:46309361 | E>D | D:547 | (47.32, 21.78, 95.06) | |
| 21:46309353 | A>V | D:550 | (44.74, 28.22, 89.76) | |
| 21:46309342 | rs145507744 | E>K | D:554 | (44.91, 28.60, 98.30) |
| 21:46309318 | N>H | D:562 | (38.64, 17.77, 114.15) | |
| 21:46309314 | rs370702628 | P>L | D:563 | (39.64, 18.83, 117.53) |
| 21:46309312 | rs5030672 | R>W | D:564 | (37.87, 14.38, 118.26) |
| 21:46309308 | R>H | D:565 | (43.21, 17.20, 114.72) | |
| 21:46309309 | rs202025124 | R>C | D:565 | (43.21, 17.20, 114.72) |
| 21:46309306 | V>I | D:566 | (39.47, 13.11, 112.04) | |
| 21:46309295 | rs369780953 | S>R | D:569 | (34.45, 13.47, 110.95) |
| 21:46309296 | S>T | D:569 | (34.45, 13.47, 110.95) | |
| 21:46309290 | R>H | D:571 | (32.30, 9.00, 105.39) | |
| 21:46309287 | G>D | D:572 | (34.68, 13.50, 103.60) | |
| 21:46309284 | R>Q | D:573 | (37.60, 14.03, 98.84) | |
| 21:46309285 | R>W | D:573 | (37.60, 14.03, 98.84) | |
| 21:46309278 | R>H | D:575 | (37.68, 18.64, 97.89) | |
| 21:46309279 | R>C | D:575 | (37.68, 18.64, 97.89) | |
| 21:46309270 | COSM1211038 COSM1534931 |
V>I | D:578 | (36.42, 21.71, 102.23) |
| 21:46309242 | L>P | D:587 | (29.42, 22.39, 106.46) | |
| 21:46309237 | L>V | D:589 | (34.30, 19.46, 110.37) | |
| 21:46309219 | COSM3551543 | G>S | D:595 | (17.62, 15.14, 109.01) |
| 21:46309212 | P>L | D:597 | (15.91, 10.08, 111.20) | |
| 21:46308803 | rs200894474 | A>T | D:607 | (21.06, -2.20, 124.52) |
| 21:46308800 | rs2230531 | E>K | D:608 | (18.81, -6.01, 125.42) |
| 21:46308784 | rs374132330 | E>V | D:613 | (23.41, -9.48, 129.62) |
| 21:46308785 | COSM3551542 | E>K | D:613 | (23.41, -9.48, 129.62) |
| 21:46308781 | rs483352819 CD109175 |
K>R | D:614 | (17.49, -9.27, 127.95) |
| 21:46308776 | P>S | D:616 | (23.02, -11.69, 122.51) | |
| 21:46308754 | rs371045998 | A>V | D:623 | (29.76, -7.99, 116.62) |
| 21:46308751 | rs201413647 | A>V | D:624 | (26.30, -6.84, 116.21) |
| 21:46308745 | rs373963624 | P>L | D:626 | (29.68, -1.74, 116.48) |
| 21:46308746 | P>T | D:626 | (29.68, -1.74, 116.48) | |
| 21:46308743 | G>R | D:627 | (28.99, 0.43, 119.93) | |
| 21:46308739 | rs368913880 | L>P | D:628 | (32.69, -0.78, 121.66) |
| 21:46308731 | S>P | D:631 | (29.61, 5.41, 129.35) | |
| 21:46308722 | P>A | D:634 | (26.02, 11.46, 132.43) | |
| 21:46308719 | rs376990045 COSM2821435 |
V>M | D:635 | (26.15, 10.77, 128.05) |
| 21:46308716 | K>E | D:636 | (23.08, 14.03, 127.72) | |
| 21:46308713 | COSM350278 | G>R | D:637 | (21.65, 14.40, 122.83) |
| 21:46308708 | R>S | D:638 | (20.61, 12.33, 118.91) | |
| 21:46308692 | D>N | D:644 | (12.44, -4.49, 125.72) | |
| 21:46308684 | rs565042973 COSM1031368 |
E>D | D:646 | (10.24, -9.58, 126.52) |
| 21:46308664 | COSM3785583 | T>M | D:653 | (21.34, 8.57, 125.92) |
| 21:46308647 | G>R | D:659 | (32.45, 7.66, 112.38) | |
| 21:46308642 | M>I | D:660 | (30.16, 5.54, 109.77) | |
| 21:46308637 | R>H | D:662 | (32.45, 4.86, 115.97) | |
| 21:46308638 | rs147238010 | R>C | D:662 | (32.45, 4.86, 115.97) |
| 21:46308608 | E>K | D:672 | (9.02, 1.20, 132.29) |
[+] ClinVar Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 21:46323397 | rs137852615 | D>Y | D:106 | (67.14, 31.80, 139.64) |
| 21:46323367 | rs137852617 | S>P | D:116 | (41.73, 30.69, 148.57) |
| 21:46323333 | rs137852611 | L>P | D:127 | (58.85, 23.77, 152.87) |
| 21:46321643 | rs137852612 | G>R | D:147 | (56.25, 36.82, 144.59) |
| 21:46321615 | rs137852614 | P>L | D:156 | (35.69, 45.91, 138.44) |
| 21:46321561 | rs137852610 | K>T | D:174 | (43.72, 36.86, 159.87) |
| 21:46321442 | rs483352814 | G>R | D:214 | (48.72, 37.79, 137.33) |
| 21:46321433 | rs179363873 | A>T | D:217 | (52.97, 40.27, 137.66) |
| 21:46320315 | rs137852618 | G>R | D:251 | (40.75, 47.26, 131.50) |
| 21:46320282 | rs137852616 | G>S | D:262 | (56.96, 46.14, 129.72) |
| 21:46314917 | rs137852613 | N>S | D:329 | (51.80, 18.32, 145.96) |
| 21:46309312 | rs5030672 | R>W | D:564 | (37.87, 14.38, 118.26) |
| 21:46309291 | rs137852609 | R>C | D:571 | (32.30, 9.00, 105.39) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 21:46330269 | COSM1414465 | T>M | D:4 | (59.57, 25.53, 81.78) |
| 21:46326937 | COSM3405470 | A>V | D:52 | (78.82, 17.85, 77.44) |
| 21:46326905 | COSM1031392 | A>T | D:63 | (76.98, 24.01, 103.38) |
| 21:46323417 | COSM1255046 | R>Q | D:99 | (71.43, 18.92, 128.38) |
| 21:46321601 | COSM1682045 | H>Y | D:161 | (36.59, 53.44, 148.19) |
| 21:46321489 | COSM2821484 | E>A | D:198 | (60.94, 37.80, 155.24) |
| 21:46319070 | COSM4624408 | P>Q | D:280 | (49.42, 41.89, 130.19) |
| 21:46314932 | COSM1616141 | S>C | D:324 | (45.97, 19.50, 146.20) |
| 21:46311847 | COSM2153318 | A>V | D:408 | (67.20, 27.55, 121.60) |
| 21:46311821 | COSM1211037 | V>M | D:417 | (72.90, 31.51, 109.96) |
| 21:46309311 | COSM1414453 | R>Q | D:564 | (37.87, 14.38, 118.26) |
| 21:46309312 | COSM1414454 | R>W | D:564 | (37.87, 14.38, 118.26) |
| 21:46309270 | COSM1534931 | V>L | D:578 | (36.42, 21.71, 102.23) |
| 21:46308785 | COSM3551542 | E>K | D:613 | (23.41, -9.48, 129.62) |