General Structure Information
| PDB ID | 3omv |
| HGNC Gene Label(s) | RAF1 |
| Structure Name | crystal structure of c-raf (raf-1) |
| Resolution | 4.0Å |
| Reference | AUTH G.HATZIVASSILIOU,K.SONG,I.YEN,B.J.BRANDHUBER,D.J.ANDERSON,AUTH 2 R.ALVARADO,M.J.LUDLAM,D.STOKOE,S.L.GLOOR,G.VIGERS,T.MORALES,AUTH 3 I.ALIAGAS,B.LIU,S.SIDERIS,K.P.HOEFLICH,B.S.JAISWAL,AUTH 4 S.SESHAGIRI,H.KOEPPEN,M.BELVIN,L.S.FRIEDMAN,S.MALEKTITL RAF INHIBITORS PRIME WILD-TYPE RAF TO ACTIVATE THE MAPKTITL 2 PATHWAY AND ENHANCE GROWTH.REF NATURE V. 464 431 2010REFN ISSN 0028-0836PMID 20130576DOI 10.1038/NATURE08833 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 264 |
| Number Of SNVs | 38 |
| Number Of Permutations | 19626 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.051 |
| p-value | 0.212 |
ClinVar
| Number Of Residues | 264 |
| Number Of SNVs | 9 |
| Number Of Permutations | 4182 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.361 |
| p-value | 0.391 |
COSMIC
| Number Of Residues | 264 |
| Number Of SNVs | 3 |
| Number Of Permutations | 18 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.667 |
| p-value | 0.472 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of ClinVar SNVs | 9 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | -0.023 |
| p-value | 0.832 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.538 |
| p-value | 0.72 |