1XWE.A | C5 – ASTRID

1XWE.A | C5

General Structure Information

PDB ID	1xwe
HGNC Gene Label(s)	C5
Structure Name	nmr structure of c345c (ntr) domain of c5 of complement
Resolution	-1.0Å
Reference	AUTH J.BRAMHAM,C.-T.THAI,D.C.SOARES,D.UHRIN,R.T.OGATA,AUTH 2 P.N.BARLOWTITL FUNCTIONAL INSIGHTS FROM THE STRUCTURE OF THETITL 2 MULTIFUNCTIONAL C345C DOMAIN OF C5 OF COMPLEMENTREF J.BIOL.CHEM. V. 280 10636 2005REFN ISSN 0021-9258PMID 15598652DOI 10.1074/JBC.M413126200

Variant Set Distributions

ExAC Variants

Number Of Residues	147
Number Of SNVs	35
Number Of Permutations	4134
Optimal Distance Threshold	16.0
K Statistic	0.264
p-value	0.251

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:123723760		A>T	A:1512	(11.24, -7.50, 13.67)
9:123722595		E>K	A:1519	(-4.67, -12.06, 6.95)
9:123722591		E>G	A:1520	(-3.62, -13.40, 1.82)
9:123722580		T>A	A:1524	(-13.03, -9.41, 9.17)
9:123722552	rs138510251	T>I	A:1533	(-7.77, 3.72, 9.11)
9:123722550	rs147051026	A>T	A:1534	(-8.20, 5.98, 5.20)
9:123722540		P>Q	A:1537	(-5.09, 12.03, 11.16)
9:123722537	rs201704886	E>G	A:1538	(-2.08, 8.90, 11.76)
9:123719632	rs375352964	I>V	A:1547	(5.54, -5.08, -6.74)
9:123719619		T>I	A:1551	(16.69, -3.80, -5.66)
9:123719620		T>A	A:1551	(16.69, -3.80, -5.66)
9:123716135		A>S	A:1574	(1.24, 11.37, -4.80)
9:123716132		E>K	A:1575	(1.40, 11.28, -9.57)
9:123716114		T>A	A:1581	(11.34, 3.00, -4.37)
9:123716110		F>S	A:1582	(7.98, 1.19, -0.79)
9:123716072		K>E	A:1595	(9.07, -9.17, -10.23)
9:123716032		Q>R	A:1608	(10.84, 14.70, 1.53)
9:123715144		Y>C	A:1617	(10.81, 11.73, -2.15)
9:123715136	rs371917232	P>S	A:1620	(10.52, 4.66, 5.30)
9:123715124		L>V	A:1624	(3.38, 3.55, 9.69)
9:123715113		I>M	A:1627	(1.29, -2.98, 3.17)
9:123715099	rs145613662	R>K	A:1632	(-2.37, -10.09, -11.02)
9:123715090		T>K	A:1635	(-12.01, -16.16, -11.16)
9:123715088		C>R	A:1636	(-8.00, -18.38, -9.25)
9:123715081		S>L	A:1638	(-12.37, -21.23, -5.85)
9:123715078		C>Y	A:1639	(-12.65, -17.87, -2.90)
9:123715073		A>T	A:1641	(-15.11, -13.34, -0.69)
9:123715065		L>F	A:1643	(-11.53, -9.76, -4.08)
9:123715064		A>T	A:1644	(-16.79, -8.36, -2.38)
9:123715054		D>G	A:1647	(-15.61, -3.47, -5.43)
9:123715052		E>K	A:1648	(-18.31, -1.10, -1.55)
9:123715045	COSM274290	A>V	A:1650	(-13.31, 1.27, -5.09)
9:123715043		E>K	A:1651	(-17.32, 3.82, -6.66)
9:123715037	rs374914766	I>V	A:1653	(-12.18, 6.89, -1.06)
9:123715030		L>S	A:1655	(-18.71, 9.25, -5.41)
9:123715026		N>K	A:1656	(-18.74, 8.40, -1.36)

1XWE.A | C5.

1XWE.A | C5

General Structure Information

Variant Set Distributions

Mapped Variants

[+] ExAC Missense Variants