3R8Q.A | FN1 – ASTRID

3R8Q.A | FN1

General Structure Information

PDB ID	3r8q
HGNC Gene Label(s)	FN1
Structure Name	structure of fibronectin domain 12-14
Resolution	2.4Å
Reference	AUTH N.R.ZACCAI,C.AGNEW,R.L.BRADYTITL STRUCTURE OF FIBRONECTIN DOMAIN 12-14REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	271
Number Of SNVs	78
Number Of Permutations	28340
Optimal Distance Threshold	8.0
K Statistic	0.031
p-value	0.896

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:216244025		T>I	A:6	(31.08, -1.11, 31.59)
2:216244019		L>R	A:8	(30.81, -5.68, 26.56)
2:216243992		S>T	A:17	(32.60, -9.61, 11.70)
2:216243984		A>T	A:20	(31.28, -3.96, 20.02)
2:216243975		T>S	A:23	(30.17, 1.98, 29.16)
2:216243951		G>R	A:31	(43.19, 4.04, 25.29)
2:216243944		R>Q	A:33	(45.02, -4.29, 24.70)
2:216243938	rs569874287	R>Q	A:35	(43.00, -10.18, 23.66)
2:216243915		G>R	A:43	(44.74, -18.88, 13.94)
2:216243908		M>R	A:45	(45.99, -12.87, 17.59)
2:216243909		M>V	A:45	(45.99, -12.87, 17.59)
2:216243896		N>S	A:49	(45.48, -0.01, 19.17)
2:216243897	rs372770694	N>H	A:49	(45.48, -0.01, 19.17)
2:216243893		L>H	A:50	(41.03, 1.97, 19.90)
2:216243894		L>F	A:50	(41.03, 1.97, 19.90)
2:216243881		S>T	A:54	(36.37, 4.72, 21.97)
2:216243873	rs369072643 COSM209959	V>M	A:57	(34.75, -2.17, 17.85)
2:216243867	rs375667567	V>L	A:59	(36.73, -6.79, 14.50)
2:216243854	rs199684110	M>T	A:63	(38.66, -17.32, 11.12)
2:216242984		V>E	A:64	(34.45, -18.63, 9.06)
2:216242985	rs140412041	V>M	A:64	(34.45, -18.63, 9.06)
2:216242981	rs145050088	A>V	A:65	(33.18, -20.80, 12.10)
2:216242976		K>Q	A:67	(34.66, -19.98, 19.92)
2:216242967		V>L	A:70	(36.68, -10.56, 23.17)
2:216242963		S>N	A:71	(39.63, -8.64, 25.40)
2:216242957	rs199890235	Y>C	A:73	(42.67, -5.03, 27.80)
2:216242949	rs145946514	K>E	A:76	(46.00, 6.53, 32.02)
2:216242942		T>I	A:78	(51.84, 2.85, 32.29)
2:216242943		T>A	A:78	(51.84, 2.85, 32.29)
2:216242918	rs140152934	G>V	A:86	(33.93, -12.09, 25.52)
2:216241391		S>N	A:95	(27.43, -14.91, -0.21)
2:216241388	rs199769361	P>L	A:96	(25.62, -11.99, -1.35)
2:216241376	rs374112006	A>V	A:100	(19.60, -9.14, -9.16)
2:216241377		A>P	A:100	(19.60, -9.14, -9.16)
2:216241374		R>C	A:101	(18.90, -8.05, -12.10)
2:216241367		T>K	A:103	(12.02, -10.79, -14.82)
2:216241359		T>A	A:106	(1.55, -9.02, -12.54)
2:216241347	rs138593265	I>F	A:110	(6.94, -9.56, -8.49)
2:216241343	rs182139649	T>N	A:111	(9.35, -12.58, -11.24)
2:216241316		T>M	A:120	(26.94, -24.27, 0.84)
2:216241293		A>T	A:128	(8.23, -7.37, 0.09)
2:216241280	rs113228862	N>S	A:132	(1.45, 1.42, 1.14)
2:216241271	rs145621410	T>I	A:135	(2.64, -5.59, 5.82)
2:216241251		K>E	A:142	(13.47, -24.44, -2.43)
2:216241248		P>A	A:143	(18.35, -24.08, -2.21)
2:216241241		V>G	A:145	(15.81, -21.46, -6.73)
2:216240426	rs201136367	T>S	A:157	(2.13, -1.44, -5.50)
2:216240423		D>G	A:158	(5.69, 0.85, -5.46)
2:216240421		Y>H	A:159	(6.05, -4.06, -3.57)
2:216240402		T>I	A:165	(21.87, -15.98, 1.06)
2:216240393		D>G	A:168	(22.48, -23.01, 8.12)
2:216240384		R>Q	A:171	(21.11, -12.29, 7.04)
2:216240385		R>W	A:171	(21.11, -12.29, 7.04)
2:216240382		S>R	A:172	(23.21, -12.31, 3.54)
2:216240375	rs148388245	P>H	A:174	(20.41, -7.35, 1.74)
2:216240372	rs144412333	V>A	A:175	(20.08, -7.71, -2.77)
2:216240364		D>N	A:178	(13.35, -1.40, -7.27)
2:216240361	rs573992192 COSM85679 COSM1648310	A>T	A:179	(9.19, -3.14, -8.32)
2:216240113	rs147592486	I>T	A:183	(-2.30, -0.66, -12.86)
2:216240111	rs201097962	D>N	A:184	(-6.07, -3.00, -11.31)
2:216240101		S>F	A:187	(-14.64, -3.94, -13.67)
2:216240102		S>P	A:187	(-14.64, -3.94, -13.67)
2:216240092	COSM4091106 COSM4091105	R>H	A:190	(-22.21, -3.45, -17.28)
2:216240083		A>V	A:193	(-27.36, 4.62, -21.83)
2:216240080		T>N	A:194	(-28.32, 4.14, -25.67)
2:216240047	rs139452116	P>L	A:205	(-13.74, 0.27, -9.03)
2:216240041	rs146612279	R>H	A:207	(-7.47, -4.10, -5.63)
2:216240042	rs372237449	R>C	A:207	(-7.47, -4.10, -5.63)
2:216240034	rs369278895 COSM1016166 COSM1591856	R>S	A:209	(-3.21, 3.95, -3.44)
2:216240027		G>S	A:212	(-7.48, 7.88, -13.32)
2:216240020		I>N	A:214	(-8.27, 6.72, -20.36)
2:216239991		P>S	A:224	(-8.90, 5.30, -31.42)
2:216239982	rs139724581	V>L	A:227	(-13.60, 10.85, -23.37)
2:216239975		P>R	A:229	(-12.77, 14.99, -19.54)
2:216239972		R>Q	A:230	(-7.83, 11.72, -19.18)
2:216239973	rs376754454	R>W	A:230	(-7.83, 11.72, -19.18)
2:216239966	COSM269188	R>H	A:232	(-13.40, 12.89, -11.06)
2:216239967	COSM1016164	R>C	A:232	(-13.40, 12.89, -11.06)
2:216239963		P>L	A:233	(-10.49, 9.93, -9.13)
2:216239960		G>V	A:234	(-14.57, 8.14, -8.29)
2:216239939		T>I	A:241	(-20.70, 12.51, -27.12)
2:216238122	COSM1016163 COSM1591857	G>V	A:246	(-25.95, 2.46, -36.07)
2:216238119		T>I	A:247	(-22.54, 2.54, -35.03)
2:216238117	COSM174865	E>K	A:248	(-21.13, -1.80, -33.17)
2:216238108		I>V	A:251	(-15.79, 1.09, -25.22)
2:216238083		N>S	A:259	(2.23, 8.37, -16.67)
2:216238068		P>L	A:264	(-7.90, -2.59, -21.53)
2:216238063		I>V	A:266	(-12.83, -4.23, -23.70)
2:216238050		K>T	A:270	(-25.51, -0.94, -32.38)