General Structure Information
| PDB ID | 2w08 |
| HGNC Gene Label(s) | APCS |
| Structure Name | the structure of serum amyloid p component bound to 0- phospho-threonine |
| Resolution | 1.7Å |
| Reference | AUTH S.E.KOLSTOE,B.H.RIDHA,V.BELLOTTI,N.WANG,AUTH 2 C.V.ROBINSON,S.J.CRUTCH,G.KEIR,R.KUKKASTENVEHMAS,AUTH 3 J.R.GALLIMORE,W.L.HUTCHINSON,P.N.HAWKINS,S.P.WOOD,AUTH 4 M.N.ROSSOR,M.B.PEPYSTITL MOLECULAR DISSECTION OF ALZHEIMERS DISEASETITL 2 NEUROPATHOLOGY BY DEPLETION OF SERUM AMYLOID PTITL 3 COMPONENT.REF PROC.NATL.ACAD.SCI.USA V. 106 7619 2009REFN ISSN 0027-8424PMID 19372378DOI 10.1073/PNAS.0902640106 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 204 |
| Number Of SNVs | 55 |
| Number Of Permutations | 10620 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.133 |
| p-value | 0.422 |
COSMIC
| Number Of Residues | 204 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3677 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.107 |
| p-value | 0.39 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.212 |
| p-value | 0.197 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
