General Structure Information
| PDB ID | 3e7c |
| HGNC Gene Label(s) | NR3C1 |
| Structure Name | glucocorticoid receptor lbd bound to gsk866 |
| Resolution | 2.15Å |
| Reference | AUTH K.P.MADAUSS,R.K.BLEDSOE,I.MCLAY,E.L.STEWART,I.J.UINGS,AUTH 2 G.WEINGARTEN,S.P.WILLIAMSTITL THE FIRST X-RAY CRYSTAL STRUCTURE OF THE GLUCOCORTICOIDTITL 2 RECEPTOR BOUND TO A NON-STEROIDAL AGONIST.REF BIOORG.MED.CHEM.LETT. V. 18 6097 2008REFN ISSN 0960-894XPMID 18952422DOI 10.1016/J.BMCL.2008.10.021 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 248 |
| Number Of SNVs | 21 |
| Number Of Permutations | 9690 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.176 |
| p-value | 0.055 |
ClinVar
| Number Of Residues | 248 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3684 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.464 |
| p-value | 0.36 |
COSMIC
| Number Of Residues | 248 |
| Number Of SNVs | 3 |
| Number Of Permutations | 18 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.602 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.217 |
| p-value | 0.314 |
Cosmic vs. ExAC
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
