General Structure Information
| PDB ID | 3con |
| HGNC Gene Label(s) | NRAS |
| Structure Name | crystal structure of the human nras gtpase bound with gdp |
| Resolution | 1.65Å |
| Reference | AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUNDTITL 2 WITH GDP.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 156 |
| Number Of SNVs | 19 |
| Number Of Permutations | 4810 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.041 |
| p-value | 0.789 |
ClinVar
| Number Of Residues | 156 |
| Number Of SNVs | 6 |
| Number Of Permutations | 966 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.533 |
| p-value | 0.002 |
COSMIC
| Number Of Residues | 156 |
| Number Of SNVs | 13 |
| Number Of Permutations | 6270 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.051 |
| p-value | 0.018 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 19 |
| Number Of ClinVar SNVs | 6 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.446 |
| p-value | 0.006 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 19 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.205 |
| p-value | 0.667 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
